Association of low-energy femoral fractures with prolonged bisphosphonate use: A case control study

B. A. Lenart, A. S. Neviaser, S. Lyman, C. C. Chang, F. Edobor-Osula, B. Steele, M. C.H. Van Der Meulen, D. G. Lorich, J. M. Lane

研究成果: Contribution to journalArticle

283 引用 (Scopus)

抜粋

Recent evidence has linked long-term bisphosphonate use with insufficiency fractures of the femur in postmenopausal women. In this case-control study, we have identified a significant association between a unique fracture of the femoral shaft, a transverse fracture in an area of thickened cortices, and long-term bisphosphonate use. Further studies are warranted. Introduction: Although clinical trials confirm the anti-fracture efficacy of bisphosphonates over 3-5 years, the long-term effects of bisphosphonate use on bone metabolism are unknown. Femoral insufficiency factures in patients on prolonged treatment have been reported. Methods: We performed a retrospective case-control study of postmenopausal women who presented with low-energy femoral fractures from 2000 to 2007. Forty-one subtrochanteric and femoral shaft fracture cases were identified and matched by age, race, and body mass index to one intertrochanteric and femoral neck fracture each. Results: Bisphosphonate use was observed in 15 of the 41 subtrochanteric/shaft cases, compared to nine of the 82 intertrochanteric/femoral neck controls (Mantel-Haenszel odds ratio (OR), 4.44 [95% confidence interval (CI) 1.77-11.35]; P∈=∈0.002). A common X-ray pattern was identified in ten of the 15 subtrochanteric/shaft cases on a bisphosphonate. This X-ray pattern was highly associated with bisphosphonate use (OR, 15.33 [95% CI 3.06-76.90]; P∈<∈0.001). Duration of bisphosphonate use was longer in subtrochanteric/shaft cases compared to both hip fracture controls groups (P∈=∈0.001). Conclusions: We found a significantly greater proportion of patients with subtrochanteric/shaft fractures to be on long-term bisphosphonates than intertrochanteric/femoral neck fractures. Bisphosphonate use was highly associated with a unique X-ray pattern. Further studies are warranted.

元の言語英語
ページ(範囲)1353-1362
ページ数10
ジャーナルOsteoporosis International
20
発行部数8
DOI
出版物ステータス出版済み - 8 2009

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

フィンガープリント Association of low-energy femoral fractures with prolonged bisphosphonate use: A case control study' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Lenart, B. A., Neviaser, A. S., Lyman, S., Chang, C. C., Edobor-Osula, F., Steele, B., Van Der Meulen, M. C. H., Lorich, D. G., & Lane, J. M. (2009). Association of low-energy femoral fractures with prolonged bisphosphonate use: A case control study. Osteoporosis International, 20(8), 1353-1362. https://doi.org/10.1007/s00198-008-0805-x