Association of perinatal factors of epilepsy in very low birth weight infants, using a nationwide database in Japan

on behalf of the Neonatal Research Network of Japan (NRNJ)

研究成果: Contribution to journalArticle査読

3 被引用数 (Scopus)

抄録

Objective: To determine clinical features of very low birth weight infants (VLBWIs) who had developed epilepsy by age 3 years. Study design: Multicenter cohort study using the Neonatal Research Network of Japan database. We analyzed clinical variables of 8431 VLBWIs who had recorded data of neurological sequelae at age 3 years. Logistic regression identified the association between variables and development of epilepsy. Result: One hundred and forty-three (1.7%) infants developed epilepsy, 683 (8.1%) showed cerebral palsy (CP), and 1114 (13.2%) had psychomotor delay. Epilepsy was associated with history of sepsis [adjusted odds ratio (AOR) 3.23], severe intraventricular hemorrhage (IVH; AOR 5.13), and cystic periventricular leukomalacia (PVL; AOR 12.7). Severe IVH and cystic PVL were also frequently associated with CP and psychomotor delay. Conclusion: Severe IVH and cystic PVL are strongly associated with development of epilepsy, as well as other neurological sequelae, and are potential critical therapeutic targets.

本文言語英語
ページ(範囲)1472-1479
ページ数8
ジャーナルJournal of Perinatology
39
11
DOI
出版ステータス出版済み - 11 1 2019

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 産婦人科学

フィンガープリント

「Association of perinatal factors of epilepsy in very low birth weight infants, using a nationwide database in Japan」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル