Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro

Kenji Furuno, Toshihiro Masatsugu, Miki Sonoda, Takehiko Sasazuki, Ken Yamamoto

研究成果: Contribution to journalArticle査読

25 被引用数 (Scopus)

抄録

SUZ12 is a Polycomb group protein that forms Polycomb repressive complexes (PRC2/3) together with EED and histone methyltransferase EZH2. Although the essential role of SUZ12 in regulating the activity of the PRC2/3 complexes has been demonstrated, additional function of this protein was suggested. Here, we show that SUZ12 interacts with WD-repeat protein MEP50 in vitro and in vivo. We show that the MEP50 binds histone H2A selectively among core histones, and mediates transcriptional repression of protein arginine methyltransferase PRMT5, which is known to methylate H2A and H4. These results suggest that SUZ12 might have a role in transcriptional regulation through physical interaction with MEP50 that can be an adaptor between PRMT5 and its substrate H2A.

本文言語英語
ページ(範囲)1051-1058
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
345
3
DOI
出版ステータス出版済み - 7 7 2006
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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