抄録
Background: It has been reported that elevated levels of serum uric acid are related to hypertension and cardiovascular disease. Recent studies, however, have found little association between hyperuricemia and hypertension. Methods and Results: The association of serum uric acid with blood pressure was examined in 3,960 Japanese male workers (18-64 years of age; mean age, 42.3±0.2 years). Systolic blood pressure was significantly correlated with serum uric acid. Multiple regression analysis also showed that both systolic and diastolic blood pressures were independently associated with serum uric acid. When subjects were divided into 6 groups according to blood pressure on the basis of the Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009), serum uric acid was elevated in a linear fashion as blood pressure increased. A similar relationship was found even in 3,608 subjects who were not taking anti-hypertensive or uric acid-lowering agents. In contrast, no relation was found between serum uric acid and blood pressure in 352 subjects taking anti-hypertensive medicine. Conclusions: Blood pressure is closely associated with serum uric acid. Serum uric acid might be associated with the increase in blood pressure, because there is no relation between serum uric acid and blood pressure in the subjects treated with anti-hypertensive medications.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 2827-2832 |
| ページ数 | 6 |
| ジャーナル | Circulation Journal |
| 巻 | 75 |
| 発行部数 | 12 |
| DOI | |
| 出版物ステータス | 出版済み - 12 5 2011 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
これを引用
Association of serum uric acid with blood pressure in Japanese men : Cross-sectional study in work-site group. / Kansui, Yasuo; Ohtsubo, Toshio; Goto, Kenichi; Sakata, Satoko; Ichishima, Kunihiko; Fukuhara, Masayo; Ohta, Yuko; Matsumura, Kiyoshi.
：: Circulation Journal, 巻 75, 番号 12, 05.12.2011, p. 2827-2832.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Association of serum uric acid with blood pressure in Japanese men
T2 - Cross-sectional study in work-site group
AU - Kansui, Yasuo
AU - Ohtsubo, Toshio
AU - Goto, Kenichi
AU - Sakata, Satoko
AU - Ichishima, Kunihiko
AU - Fukuhara, Masayo
AU - Ohta, Yuko
AU - Matsumura, Kiyoshi
PY - 2011/12/5
Y1 - 2011/12/5
N2 - Background: It has been reported that elevated levels of serum uric acid are related to hypertension and cardiovascular disease. Recent studies, however, have found little association between hyperuricemia and hypertension. Methods and Results: The association of serum uric acid with blood pressure was examined in 3,960 Japanese male workers (18-64 years of age; mean age, 42.3±0.2 years). Systolic blood pressure was significantly correlated with serum uric acid. Multiple regression analysis also showed that both systolic and diastolic blood pressures were independently associated with serum uric acid. When subjects were divided into 6 groups according to blood pressure on the basis of the Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009), serum uric acid was elevated in a linear fashion as blood pressure increased. A similar relationship was found even in 3,608 subjects who were not taking anti-hypertensive or uric acid-lowering agents. In contrast, no relation was found between serum uric acid and blood pressure in 352 subjects taking anti-hypertensive medicine. Conclusions: Blood pressure is closely associated with serum uric acid. Serum uric acid might be associated with the increase in blood pressure, because there is no relation between serum uric acid and blood pressure in the subjects treated with anti-hypertensive medications.
AB - Background: It has been reported that elevated levels of serum uric acid are related to hypertension and cardiovascular disease. Recent studies, however, have found little association between hyperuricemia and hypertension. Methods and Results: The association of serum uric acid with blood pressure was examined in 3,960 Japanese male workers (18-64 years of age; mean age, 42.3±0.2 years). Systolic blood pressure was significantly correlated with serum uric acid. Multiple regression analysis also showed that both systolic and diastolic blood pressures were independently associated with serum uric acid. When subjects were divided into 6 groups according to blood pressure on the basis of the Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009), serum uric acid was elevated in a linear fashion as blood pressure increased. A similar relationship was found even in 3,608 subjects who were not taking anti-hypertensive or uric acid-lowering agents. In contrast, no relation was found between serum uric acid and blood pressure in 352 subjects taking anti-hypertensive medicine. Conclusions: Blood pressure is closely associated with serum uric acid. Serum uric acid might be associated with the increase in blood pressure, because there is no relation between serum uric acid and blood pressure in the subjects treated with anti-hypertensive medications.
UR - http://www.scopus.com/inward/record.url?scp=82455198847&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82455198847&partnerID=8YFLogxK
U2 - 10.1253/circj.CJ-11-0592
DO - 10.1253/circj.CJ-11-0592
M3 - Article
C2 - 22001290
AN - SCOPUS:82455198847
VL - 75
SP - 2827
EP - 2832
JO - Circulation Journal
JF - Circulation Journal
SN - 1346-9843
IS - 12
ER -