Association of the interleukin-4 receptor α chain with p47(phox), an activator of the phagocyte NADPH oxidase in B cells

K. Izuhara, Y. Arinobu, H. Sumimoto, H. Nunoi, R. Takeya, K. Higuchi, K. Takeshige, N. Hamasaki, N. Harada

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

抄録

Interleukin (IL)-4 plays an important role in IgE synthesis in B cells and in Th2 differentiation in T cells, IL-4 conducts its biological activities through binding to the IL-4 receptor (IL-4R) on the surface of target cells. IL-4R are thought to be composed of the IL-4R α chain (IL- 4Rα) and either the IL-2R γ chain or the IL-13R α chain. We have previously shown that the membrane-proximal portion in the cytoplasmic domain of the human IL-4Rα (hIL-4Rα) is critical for proliferation, generation of germline ε transcript, and activation of STAT6, based on analyses of truncated hIL-4Rαs. In this study, we found that p47p(phox), an activator of the phagocyte NADPH oxidase, binds to this portion by the two-hybrid system. Furthermore, we observed the association of p47(phox) with the hIL-4Rα in B cells derived from a normal donor. These results suggest that p47(phox) is involved in the signal transduction of IL-4 in B cells. However, activation of STAT6, CD23 expression, and IgE synthesis induced by IL-4 were not affected in p47(phox)-deficient patients, which raises the possibility that p47(phox) may be important in other signaling activities as well in B cells.

元の言語英語
ページ(範囲)45-52
ページ数8
ジャーナルMolecular Immunology
36
発行部数1
DOI
出版物ステータス出版済み - 1 1 1999

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Interleukin-4 Receptors
NADPH Oxidase
Interleukins
Phagocytes
B-Lymphocytes
Interleukin-4
Immunoglobulin E
Signal Transduction
4-ethoxymethylene-2-phenyl-2-oxazoline-5-one
Tissue Donors
T-Lymphocytes
Membranes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Molecular Biology

これを引用

Association of the interleukin-4 receptor α chain with p47(phox), an activator of the phagocyte NADPH oxidase in B cells. / Izuhara, K.; Arinobu, Y.; Sumimoto, H.; Nunoi, H.; Takeya, R.; Higuchi, K.; Takeshige, K.; Hamasaki, N.; Harada, N.

:: Molecular Immunology, 巻 36, 番号 1, 01.01.1999, p. 45-52.

研究成果: ジャーナルへの寄稿記事

Izuhara, K. ; Arinobu, Y. ; Sumimoto, H. ; Nunoi, H. ; Takeya, R. ; Higuchi, K. ; Takeshige, K. ; Hamasaki, N. ; Harada, N. / Association of the interleukin-4 receptor α chain with p47(phox), an activator of the phagocyte NADPH oxidase in B cells. :: Molecular Immunology. 1999 ; 巻 36, 番号 1. pp. 45-52.
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AU - Takeya, R.

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