Association of the RIP2 gene with childhood atopic asthma

Kazuko Nakashima, Tomomitsu Hirota, Yoichi Suzuki, Mitsuteru Akahoshi, Makiko Shimizu, Aya Jodo, Satoru Doi, Kimie Fujita, Motohiro Ebisawa, Shigemi Yoshihara, Tadao Enomoto, Taro Shirakawa, Fumio Kishi, Yusuke Nakamura, Mayumi Tamari

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

抄録

Background: Receptor-interacting protein (RIP)-2 is a serine/threonine kinase containing a caspase recruitment domain (CARD) that is involved in the Toll-like receptor-signaling pathway. Although associations between endotoxin exposure or respiratory infection and asthma have been recognized, the genetic influences in these conditions are unclear. The aim of our study was to examine whether polymorphisms or haplotypes in RIP2 were associated with childhood atopic asthma in a Japanese population. Methods: We screened the RIP2 gene for polymorphisms by direct sequencing and characterized the linkage disequilibrium (LD) mapping of the gene. Seven variants were genotyped in childhood atopic asthma (n = 300) and normal controls (n = 637). We conducted case-control and case-only association studies between the variants and asthma-related phenotypes. Haplotype association analyses were also performed. Results: A total of 31 variants were identified and none of the alleles or haplotypes of RIP2 were associated with asthma susceptibility. In the case-only study, an association between an RIP2 promoter polymorphism and childhood severe asthma (P = 0.0032; odds ratio (OR) 3.37, 95% confidence interval (CI) 1.45-7.87) was observed. Conclusions: Although polymorphisms in RIP2 are not likely to be associated with the development of asthma, the genetic variants might contribute to asthma severity in the Japanese population.

元の言語英語
ページ(範囲)77-83
ページ数7
ジャーナルAllergology International
55
発行部数1
DOI
出版物ステータス出版済み - 3 2006

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Asthma
Genes
Haplotypes
Receptor-Interacting Protein Serine-Threonine Kinases
Chromosome Mapping
Toll-Like Receptors
Protein-Serine-Threonine Kinases
Linkage Disequilibrium
Endotoxins
Respiratory Tract Infections
Population
Alleles
Odds Ratio
Confidence Intervals
Phenotype

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

これを引用

Nakashima, K., Hirota, T., Suzuki, Y., Akahoshi, M., Shimizu, M., Jodo, A., ... Tamari, M. (2006). Association of the RIP2 gene with childhood atopic asthma. Allergology International, 55(1), 77-83. https://doi.org/10.2332/allergolint.55.77

Association of the RIP2 gene with childhood atopic asthma. / Nakashima, Kazuko; Hirota, Tomomitsu; Suzuki, Yoichi; Akahoshi, Mitsuteru; Shimizu, Makiko; Jodo, Aya; Doi, Satoru; Fujita, Kimie; Ebisawa, Motohiro; Yoshihara, Shigemi; Enomoto, Tadao; Shirakawa, Taro; Kishi, Fumio; Nakamura, Yusuke; Tamari, Mayumi.

:: Allergology International, 巻 55, 番号 1, 03.2006, p. 77-83.

研究成果: ジャーナルへの寄稿記事

Nakashima, K, Hirota, T, Suzuki, Y, Akahoshi, M, Shimizu, M, Jodo, A, Doi, S, Fujita, K, Ebisawa, M, Yoshihara, S, Enomoto, T, Shirakawa, T, Kishi, F, Nakamura, Y & Tamari, M 2006, 'Association of the RIP2 gene with childhood atopic asthma', Allergology International, 巻. 55, 番号 1, pp. 77-83. https://doi.org/10.2332/allergolint.55.77
Nakashima, Kazuko ; Hirota, Tomomitsu ; Suzuki, Yoichi ; Akahoshi, Mitsuteru ; Shimizu, Makiko ; Jodo, Aya ; Doi, Satoru ; Fujita, Kimie ; Ebisawa, Motohiro ; Yoshihara, Shigemi ; Enomoto, Tadao ; Shirakawa, Taro ; Kishi, Fumio ; Nakamura, Yusuke ; Tamari, Mayumi. / Association of the RIP2 gene with childhood atopic asthma. :: Allergology International. 2006 ; 巻 55, 番号 1. pp. 77-83.
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title = "Association of the RIP2 gene with childhood atopic asthma",
abstract = "Background: Receptor-interacting protein (RIP)-2 is a serine/threonine kinase containing a caspase recruitment domain (CARD) that is involved in the Toll-like receptor-signaling pathway. Although associations between endotoxin exposure or respiratory infection and asthma have been recognized, the genetic influences in these conditions are unclear. The aim of our study was to examine whether polymorphisms or haplotypes in RIP2 were associated with childhood atopic asthma in a Japanese population. Methods: We screened the RIP2 gene for polymorphisms by direct sequencing and characterized the linkage disequilibrium (LD) mapping of the gene. Seven variants were genotyped in childhood atopic asthma (n = 300) and normal controls (n = 637). We conducted case-control and case-only association studies between the variants and asthma-related phenotypes. Haplotype association analyses were also performed. Results: A total of 31 variants were identified and none of the alleles or haplotypes of RIP2 were associated with asthma susceptibility. In the case-only study, an association between an RIP2 promoter polymorphism and childhood severe asthma (P = 0.0032; odds ratio (OR) 3.37, 95{\%} confidence interval (CI) 1.45-7.87) was observed. Conclusions: Although polymorphisms in RIP2 are not likely to be associated with the development of asthma, the genetic variants might contribute to asthma severity in the Japanese population.",
author = "Kazuko Nakashima and Tomomitsu Hirota and Yoichi Suzuki and Mitsuteru Akahoshi and Makiko Shimizu and Aya Jodo and Satoru Doi and Kimie Fujita and Motohiro Ebisawa and Shigemi Yoshihara and Tadao Enomoto and Taro Shirakawa and Fumio Kishi and Yusuke Nakamura and Mayumi Tamari",
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T1 - Association of the RIP2 gene with childhood atopic asthma

AU - Nakashima, Kazuko

AU - Hirota, Tomomitsu

AU - Suzuki, Yoichi

AU - Akahoshi, Mitsuteru

AU - Shimizu, Makiko

AU - Jodo, Aya

AU - Doi, Satoru

AU - Fujita, Kimie

AU - Ebisawa, Motohiro

AU - Yoshihara, Shigemi

AU - Enomoto, Tadao

AU - Shirakawa, Taro

AU - Kishi, Fumio

AU - Nakamura, Yusuke

AU - Tamari, Mayumi

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Y1 - 2006/3

N2 - Background: Receptor-interacting protein (RIP)-2 is a serine/threonine kinase containing a caspase recruitment domain (CARD) that is involved in the Toll-like receptor-signaling pathway. Although associations between endotoxin exposure or respiratory infection and asthma have been recognized, the genetic influences in these conditions are unclear. The aim of our study was to examine whether polymorphisms or haplotypes in RIP2 were associated with childhood atopic asthma in a Japanese population. Methods: We screened the RIP2 gene for polymorphisms by direct sequencing and characterized the linkage disequilibrium (LD) mapping of the gene. Seven variants were genotyped in childhood atopic asthma (n = 300) and normal controls (n = 637). We conducted case-control and case-only association studies between the variants and asthma-related phenotypes. Haplotype association analyses were also performed. Results: A total of 31 variants were identified and none of the alleles or haplotypes of RIP2 were associated with asthma susceptibility. In the case-only study, an association between an RIP2 promoter polymorphism and childhood severe asthma (P = 0.0032; odds ratio (OR) 3.37, 95% confidence interval (CI) 1.45-7.87) was observed. Conclusions: Although polymorphisms in RIP2 are not likely to be associated with the development of asthma, the genetic variants might contribute to asthma severity in the Japanese population.

AB - Background: Receptor-interacting protein (RIP)-2 is a serine/threonine kinase containing a caspase recruitment domain (CARD) that is involved in the Toll-like receptor-signaling pathway. Although associations between endotoxin exposure or respiratory infection and asthma have been recognized, the genetic influences in these conditions are unclear. The aim of our study was to examine whether polymorphisms or haplotypes in RIP2 were associated with childhood atopic asthma in a Japanese population. Methods: We screened the RIP2 gene for polymorphisms by direct sequencing and characterized the linkage disequilibrium (LD) mapping of the gene. Seven variants were genotyped in childhood atopic asthma (n = 300) and normal controls (n = 637). We conducted case-control and case-only association studies between the variants and asthma-related phenotypes. Haplotype association analyses were also performed. Results: A total of 31 variants were identified and none of the alleles or haplotypes of RIP2 were associated with asthma susceptibility. In the case-only study, an association between an RIP2 promoter polymorphism and childhood severe asthma (P = 0.0032; odds ratio (OR) 3.37, 95% confidence interval (CI) 1.45-7.87) was observed. Conclusions: Although polymorphisms in RIP2 are not likely to be associated with the development of asthma, the genetic variants might contribute to asthma severity in the Japanese population.

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