Association study of 71 European Crohn's disease susceptibility loci in a Japanese population

Atsushi Hirano, Keiko Yamazaki, Junji Umeno, Kyota Ashikawa, Masayuki Aoki, Takayuki Matsumoto, Shotaro Nakamura, Toshiharu Ninomiya, Toshiyuki Matsui, Fumihito Hirai, Takaaki Kawaguchi, Masakazu Takazoe, Hiroki Tanaka, Satoshi Motoya, Yutaka Kiyohara, Takanari Kitazono, Yusuke Nakamura, Naoyuki Kamatani, Michiaki Kubo

研究成果: Contribution to journalArticle査読

51 被引用数 (Scopus)

抄録

Background: A large-scale meta-analysis of a series of European genome-wide association studies revealed 71 susceptibility loci for Crohn's disease (CD). However, it is not clear whether these susceptibility loci are also shared with Japanese populations. Methods: We genotyped 71 single-nucleotide polymorphisms (SNPs) comprising 1311 CD cases and 6585 controls of Japanese descent, and their associations with CD were evaluated using the Cochran-Armitage trend test. In addition, genotype-phenotype analyses were conducted on the SNPs showing associations with Japanese CD based on the Montreal classification. Results: Twenty-seven SNPs showed at least nominal association (P , 0.05) and 11 of them remained significant even after Bonferroni correction (P , 0.0007). Despite high statistical power, we could not find any association in 17 loci. Moreover, SNPs in 9 loci were rare or absent in the Japanese population. Genetic variations involved in the innate immune system (NOD2, ATG16L1, and IRGM) showed no association with CD susceptibility in the Japanese population. Genotype-phenotype analyses showed that rs3810936, a marker of TNFSF15, correlated with severe CD phenotypes. Conclusions: Our study suggests that there is a differential genetic background of CD susceptibility between Japanese and European populations.

本文言語英語
ページ(範囲)526-533
ページ数8
ジャーナルInflammatory bowel diseases
19
3
DOI
出版ステータス出版済み - 3 2013

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 消化器病学

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