Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia

Hiroki Shibata, Akiko Joo, Yo Fujii, Ayako Tani, Chieko Makino, Naotsugu Hirata, Rumiko Kikuta, Hideaki Ninomiya, Nobutada Tashiro, Yasuyuki Fukumaki

研究成果: ジャーナルへの寄稿記事

30 引用 (Scopus)

抄録

The glutamatergic dysfunction hypothesis suggests genes involved in glutamatergic transmission as candidates for schizophrenia susceptibility genes. We screened single nucleotide polymorphisms (SNPs) in the entire coding sequence of the GluR5 kainate receptor gene, GRIK1, by polymerase chain reaction-single strand conformation polymorphism and direct sequencing. We identified six SNPs including three known ones, 522A/C (174T, synonymous), 1173C/T (391D, synonymous), and 2705C/T (902L/S), as well as three novel ones, 995C/T (332A/V), 2400C/T (800L, synonymous), and 2585A/G (862R/Q). We genotyped Japanese samples of schizophrenia (n = 193-203) and healthy controls (n = 199-215) for three SNPs those were commonly observed in our samples, 522A/C, 1173C/T, and 2705C/T. We observed no significant associations of the SNPs and their haplotypes with schizophrenia. Therefore, we conclude that GRIK1 does not play a major role in schizophrenia pathogenesis in the Japanese population.

元の言語英語
ページ(範囲)139-144
ページ数6
ジャーナルPsychiatric Genetics
11
発行部数3
DOI
出版物ステータス出版済み - 10 30 2001

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Single Nucleotide Polymorphism
Schizophrenia
Genes
Haplotypes
Polymerase Chain Reaction
Gluk1 kainate receptor
Population

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

これを引用

Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia. / Shibata, Hiroki; Joo, Akiko; Fujii, Yo; Tani, Ayako; Makino, Chieko; Hirata, Naotsugu; Kikuta, Rumiko; Ninomiya, Hideaki; Tashiro, Nobutada; Fukumaki, Yasuyuki.

:: Psychiatric Genetics, 巻 11, 番号 3, 30.10.2001, p. 139-144.

研究成果: ジャーナルへの寄稿記事

Shibata, H, Joo, A, Fujii, Y, Tani, A, Makino, C, Hirata, N, Kikuta, R, Ninomiya, H, Tashiro, N & Fukumaki, Y 2001, 'Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia', Psychiatric Genetics, 巻. 11, 番号 3, pp. 139-144. https://doi.org/10.1097/00041444-200109000-00005
Shibata, Hiroki ; Joo, Akiko ; Fujii, Yo ; Tani, Ayako ; Makino, Chieko ; Hirata, Naotsugu ; Kikuta, Rumiko ; Ninomiya, Hideaki ; Tashiro, Nobutada ; Fukumaki, Yasuyuki. / Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia. :: Psychiatric Genetics. 2001 ; 巻 11, 番号 3. pp. 139-144.
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