Associations between metal concentrations in whole blood and placenta previa and placenta accreta: The Japan Environment and Children's Study (JECS)

Mayumi Tsuji, Eiji Shibata, David J. Askew, Seiichi Morokuma, Yukiyo Aiko, Ayako Senju, Shunsuke Araki, Masafumi Sanefuji, Yasuhiro Ishihara, Rie Tanaka, Koichi Kusuhara, Toshihiro Kawamoto, Hirohisa Saito, Reiko Kishi, Nobuo Yaegashi, Koichi Hashimoto, Chisato Mori, Shuichi Ito, Zentaro Yamagata, Hidekuni InaderaMichihiro Kamijima, Takeo Nakayama, Hiroyasu Iso, Masayuki Shima, Yasuaki Hirooka, Narufumi Suganuma, Takahiko Katoh

研究成果: ジャーナルへの寄稿記事

抄録

Background: Placenta previa and placenta accreta associate with high morbidity and mortality for both mothers and fetus. Metal exposure may have relationships with placenta previa and placenta accreta. This study analyzed the associations between maternal metal (cadmium [Cd], lead [Pb], mercury [Hg], selenium [Se], and manganese [Mn]) concentrations and placenta previa and placenta accreta. Methods: We recruited 17,414 women with singleton pregnancies. Data from a self-administered questionnaire regarding the first trimester and medical records after delivery were analyzed. Maternal blood samples were collected to measure metal concentrations. The subjects were classified into four quartiles (Q1, Q2, Q3, and Q4) according to metal concentrations. Results: The odds ratio for placenta previa was significantly higher among subjects with Q4 Cd than those with Q1 Cd. The odds ratio for placenta previa was significantly higher for subjects with Q2 Pb than those with Q1 Pb. Conclusion: Participants with placenta previa had higher Cd concentrations. However, this study was cross-sectional and lacked important information related to Cd concentration, such as detailed smoking habits and sources of Cd intake. In addition, the subjects in this study comprised ordinary pregnant Japanese women, and it was impossible to observe the relationship between a wide range of Cd exposure and placenta previa. Therefore, epidemiological and experimental studies are warranted to verify the relationship between Cd exposure and pregnancy abnormalities.

元の言語英語
記事番号40
ジャーナルEnvironmental health and preventive medicine
24
発行部数1
DOI
出版物ステータス出版済み - 6 7 2019

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Placenta Accreta
Placenta Previa
Cadmium
Japan
Metals
Mothers
Odds Ratio
Pregnancy
First Pregnancy Trimester
Manganese
Selenium
Mercury
Habits
Medical Records
Pregnant Women
Epidemiologic Studies
Fetus
Cross-Sectional Studies
Smoking
Morbidity

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

これを引用

Associations between metal concentrations in whole blood and placenta previa and placenta accreta : The Japan Environment and Children's Study (JECS). / Tsuji, Mayumi; Shibata, Eiji; Askew, David J.; Morokuma, Seiichi; Aiko, Yukiyo; Senju, Ayako; Araki, Shunsuke; Sanefuji, Masafumi; Ishihara, Yasuhiro; Tanaka, Rie; Kusuhara, Koichi; Kawamoto, Toshihiro; Saito, Hirohisa; Kishi, Reiko; Yaegashi, Nobuo; Hashimoto, Koichi; Mori, Chisato; Ito, Shuichi; Yamagata, Zentaro; Inadera, Hidekuni; Kamijima, Michihiro; Nakayama, Takeo; Iso, Hiroyasu; Shima, Masayuki; Hirooka, Yasuaki; Suganuma, Narufumi; Katoh, Takahiko.

:: Environmental health and preventive medicine, 巻 24, 番号 1, 40, 07.06.2019.

研究成果: ジャーナルへの寄稿記事

Tsuji, M, Shibata, E, Askew, DJ, Morokuma, S, Aiko, Y, Senju, A, Araki, S, Sanefuji, M, Ishihara, Y, Tanaka, R, Kusuhara, K, Kawamoto, T, Saito, H, Kishi, R, Yaegashi, N, Hashimoto, K, Mori, C, Ito, S, Yamagata, Z, Inadera, H, Kamijima, M, Nakayama, T, Iso, H, Shima, M, Hirooka, Y, Suganuma, N & Katoh, T 2019, 'Associations between metal concentrations in whole blood and placenta previa and placenta accreta: The Japan Environment and Children's Study (JECS)', Environmental health and preventive medicine, 巻. 24, 番号 1, 40. https://doi.org/10.1186/s12199-019-0795-7
Tsuji, Mayumi ; Shibata, Eiji ; Askew, David J. ; Morokuma, Seiichi ; Aiko, Yukiyo ; Senju, Ayako ; Araki, Shunsuke ; Sanefuji, Masafumi ; Ishihara, Yasuhiro ; Tanaka, Rie ; Kusuhara, Koichi ; Kawamoto, Toshihiro ; Saito, Hirohisa ; Kishi, Reiko ; Yaegashi, Nobuo ; Hashimoto, Koichi ; Mori, Chisato ; Ito, Shuichi ; Yamagata, Zentaro ; Inadera, Hidekuni ; Kamijima, Michihiro ; Nakayama, Takeo ; Iso, Hiroyasu ; Shima, Masayuki ; Hirooka, Yasuaki ; Suganuma, Narufumi ; Katoh, Takahiko. / Associations between metal concentrations in whole blood and placenta previa and placenta accreta : The Japan Environment and Children's Study (JECS). :: Environmental health and preventive medicine. 2019 ; 巻 24, 番号 1.
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title = "Associations between metal concentrations in whole blood and placenta previa and placenta accreta: The Japan Environment and Children's Study (JECS)",
abstract = "Background: Placenta previa and placenta accreta associate with high morbidity and mortality for both mothers and fetus. Metal exposure may have relationships with placenta previa and placenta accreta. This study analyzed the associations between maternal metal (cadmium [Cd], lead [Pb], mercury [Hg], selenium [Se], and manganese [Mn]) concentrations and placenta previa and placenta accreta. Methods: We recruited 17,414 women with singleton pregnancies. Data from a self-administered questionnaire regarding the first trimester and medical records after delivery were analyzed. Maternal blood samples were collected to measure metal concentrations. The subjects were classified into four quartiles (Q1, Q2, Q3, and Q4) according to metal concentrations. Results: The odds ratio for placenta previa was significantly higher among subjects with Q4 Cd than those with Q1 Cd. The odds ratio for placenta previa was significantly higher for subjects with Q2 Pb than those with Q1 Pb. Conclusion: Participants with placenta previa had higher Cd concentrations. However, this study was cross-sectional and lacked important information related to Cd concentration, such as detailed smoking habits and sources of Cd intake. In addition, the subjects in this study comprised ordinary pregnant Japanese women, and it was impossible to observe the relationship between a wide range of Cd exposure and placenta previa. Therefore, epidemiological and experimental studies are warranted to verify the relationship between Cd exposure and pregnancy abnormalities.",
author = "Mayumi Tsuji and Eiji Shibata and Askew, {David J.} and Seiichi Morokuma and Yukiyo Aiko and Ayako Senju and Shunsuke Araki and Masafumi Sanefuji and Yasuhiro Ishihara and Rie Tanaka and Koichi Kusuhara and Toshihiro Kawamoto and Hirohisa Saito and Reiko Kishi and Nobuo Yaegashi and Koichi Hashimoto and Chisato Mori and Shuichi Ito and Zentaro Yamagata and Hidekuni Inadera and Michihiro Kamijima and Takeo Nakayama and Hiroyasu Iso and Masayuki Shima and Yasuaki Hirooka and Narufumi Suganuma and Takahiko Katoh",
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T1 - Associations between metal concentrations in whole blood and placenta previa and placenta accreta

T2 - The Japan Environment and Children's Study (JECS)

AU - Tsuji, Mayumi

AU - Shibata, Eiji

AU - Askew, David J.

AU - Morokuma, Seiichi

AU - Aiko, Yukiyo

AU - Senju, Ayako

AU - Araki, Shunsuke

AU - Sanefuji, Masafumi

AU - Ishihara, Yasuhiro

AU - Tanaka, Rie

AU - Kusuhara, Koichi

AU - Kawamoto, Toshihiro

AU - Saito, Hirohisa

AU - Kishi, Reiko

AU - Yaegashi, Nobuo

AU - Hashimoto, Koichi

AU - Mori, Chisato

AU - Ito, Shuichi

AU - Yamagata, Zentaro

AU - Inadera, Hidekuni

AU - Kamijima, Michihiro

AU - Nakayama, Takeo

AU - Iso, Hiroyasu

AU - Shima, Masayuki

AU - Hirooka, Yasuaki

AU - Suganuma, Narufumi

AU - Katoh, Takahiko

PY - 2019/6/7

Y1 - 2019/6/7

N2 - Background: Placenta previa and placenta accreta associate with high morbidity and mortality for both mothers and fetus. Metal exposure may have relationships with placenta previa and placenta accreta. This study analyzed the associations between maternal metal (cadmium [Cd], lead [Pb], mercury [Hg], selenium [Se], and manganese [Mn]) concentrations and placenta previa and placenta accreta. Methods: We recruited 17,414 women with singleton pregnancies. Data from a self-administered questionnaire regarding the first trimester and medical records after delivery were analyzed. Maternal blood samples were collected to measure metal concentrations. The subjects were classified into four quartiles (Q1, Q2, Q3, and Q4) according to metal concentrations. Results: The odds ratio for placenta previa was significantly higher among subjects with Q4 Cd than those with Q1 Cd. The odds ratio for placenta previa was significantly higher for subjects with Q2 Pb than those with Q1 Pb. Conclusion: Participants with placenta previa had higher Cd concentrations. However, this study was cross-sectional and lacked important information related to Cd concentration, such as detailed smoking habits and sources of Cd intake. In addition, the subjects in this study comprised ordinary pregnant Japanese women, and it was impossible to observe the relationship between a wide range of Cd exposure and placenta previa. Therefore, epidemiological and experimental studies are warranted to verify the relationship between Cd exposure and pregnancy abnormalities.

AB - Background: Placenta previa and placenta accreta associate with high morbidity and mortality for both mothers and fetus. Metal exposure may have relationships with placenta previa and placenta accreta. This study analyzed the associations between maternal metal (cadmium [Cd], lead [Pb], mercury [Hg], selenium [Se], and manganese [Mn]) concentrations and placenta previa and placenta accreta. Methods: We recruited 17,414 women with singleton pregnancies. Data from a self-administered questionnaire regarding the first trimester and medical records after delivery were analyzed. Maternal blood samples were collected to measure metal concentrations. The subjects were classified into four quartiles (Q1, Q2, Q3, and Q4) according to metal concentrations. Results: The odds ratio for placenta previa was significantly higher among subjects with Q4 Cd than those with Q1 Cd. The odds ratio for placenta previa was significantly higher for subjects with Q2 Pb than those with Q1 Pb. Conclusion: Participants with placenta previa had higher Cd concentrations. However, this study was cross-sectional and lacked important information related to Cd concentration, such as detailed smoking habits and sources of Cd intake. In addition, the subjects in this study comprised ordinary pregnant Japanese women, and it was impossible to observe the relationship between a wide range of Cd exposure and placenta previa. Therefore, epidemiological and experimental studies are warranted to verify the relationship between Cd exposure and pregnancy abnormalities.

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DO - 10.1186/s12199-019-0795-7

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