Previous studies have suggested that the human leukocyte antigen (HLA) is involved in the etiology of Crohn's disease (CD); however, few reports are available on the association between HLA class I antigens and CD in Japan. In this study, we performed association analysis of HLA class I antigens in CD using 208 Japanese patients and 384 healthy controls. We identified novel positive associations between CD and HLA-A∗02:01 (odds ratio (OR)=1.64, P=0.016) and HLA-A∗02:07 (OR=2.31, P=0.0067) and confirmed previously reported positive associations between CD and HLA-Cw∗14:02 (OR=2.18, P=0.0021) and HLA-B∗51:01 (OR=1.70, P=0.033). We also identified novel negative associations between CD and HLA-A∗24:02 (OR=0.60, P=0.0047) and HLA-B∗07:02 (OR=0.38, P=0.0041). Although the associations were not significant after full Bonferroni correction, we suggested that HLA class I genes have dual functions, susceptibility and resistance in controlling the development of CD.
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