Astrocytopathy in Baló's disease

研究成果: ジャーナルへの寄稿評論記事

25 引用 (Scopus)

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Baló's disease is characterized by alternating rings of demyelination and preserved myelin. As additional multiple sclerosis (MS)-like lesions often coexist in Baló's cases, Baló's disease is regarded as a variant of MS. In demyelinated areas, many hypertrophic astrocytes are present in close contact with oligodendrocytes, which often show apoptotic features. In the outermost layer of preserved myelin, stress proteins involved in tissue preconditioning are abundant in oligodendrocytes. The peri-plaque perimeter is thus assumed resistant to subsequent attack, thereby leaving a layer of preserved myelin. In some cases, Baló's concentric rings develop step by step in a centrifugal direction, whereas many other cases show simultaneous enhancement of multiple rings. Therefore tissue preconditioning and successive ring formation does not fully describe the mechanism of the disease. We recently reported that in four Filipino Baló's patients, aquaporin-4 (AQP4) was extensively lost in glial fibrillary acidic protein-positive hypertrophic astrocytes, both in demyelinated and myelinated layers of all actively demyelinating lesions. None of six further patients with MRI-confirmed Baló's disease were seropositive for anti-AQP4 antibody. I propose that AQP4 astrocytopathy, in the absence of anti-AQP4 antibody, is characteristic of Baló's disease. This hypothesis should be tested in future experimental studies.

元の言語英語
ページ(範囲)771-779
ページ数9
ジャーナルMultiple Sclerosis Journal
17
発行部数7
DOI
出版物ステータス出版済み - 1 1 2011

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Aquaporin 4
Oligodendroglia
Myelin Sheath
Astrocytes
Multiple Sclerosis
Myelin Proteins
Antibodies
Glial Fibrillary Acidic Protein
Demyelinating Diseases
Heat-Shock Proteins

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

これを引用

Astrocytopathy in Baló's disease. / Kira, Jun-Ichi.

:: Multiple Sclerosis Journal, 巻 17, 番号 7, 01.01.2011, p. 771-779.

研究成果: ジャーナルへの寄稿評論記事

Kira, Jun-Ichi. / Astrocytopathy in Baló's disease. :: Multiple Sclerosis Journal. 2011 ; 巻 17, 番号 7. pp. 771-779.
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