抄録
The safety and efficacy of an IFN-free regimen using asunaprevir (ASV) and daclatasvir (DCV) for recurrent hepatitis C virus (HCV) infection after liver transplantation (LT) have not been evaluated in Japan. A multicenter study of LT recipients (n = 74) with recurrent HCV genotype 1b infection treated with ASV-DCV for 24 weeks was performed. Medical history was positive for pegylated interferon and ribavirin (Peg-IFN/RBV) in 40 (54.1%) patients, and for simeprevir (SMV) with Peg-IFN/RBV in 12 (16.2%) patients. Resistance-associated variants (RAVs) were positive at D168 (n = 1) in the NS3, and at L31 (n = 4), Y93 (n = 4), and L31/Y93 (n = 1) in the NS5A region of the HCV genome. Sixty-one (82.4%) patients completed the 24-week treatment protocol. Although sustained viral response (SVR) was achieved in 49 (80.3%) patients, it was achieved in only two (16.7%) patients among those with histories of receiving SMV (n = 12). Univariate analysis showed that a history of SMV (P <.01) and the presence of mutations in NS5A (P =.02) were the significant factors for no-SVR. By excluding the patients with either a history of SMV-based treatment or RAVs in NS3/NS5A, the SVR rate was 96.4%. By excluding the patients with a history of SMV and those with RAVs in NS3/NS5A, viral clearance of ASV-DCV was favorable, with a high SVR rate.
| 元の言語 | 英語 |
|---|---|
| 記事番号 | e13109 |
| ジャーナル | Clinical Transplantation |
| 巻 | 31 |
| 発行部数 | 11 |
| DOI | |
| 出版物ステータス | 出版済み - 11 1 2017 |
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All Science Journal Classification (ASJC) codes
- Transplantation
これを引用
Asunaprevir and daclatasvir for recurrent hepatitis C after liver transplantation : A Japanese multicenter experience. / Ikegami, Toru; Ueda, Yoshihide; Akamatsu, Nobuhisa; Ishiyama, Kohei; Goto, Ryoichi; Soyama, Akihiko; Kuramitsu, Kaori; Honda, Masaki; Shinoda, Masahiro; Yoshizumi, Tomoharu; Okajima, Hideaki; Kitagawa, Yuko; Inomata, Yukihiro; Ku, Yonson; Eguchi, Susumu; Taketomi, Akinobu; Ohdan, Hideki; Kokudo, Norihiro; Shimada, Mitsuo; Yanaga, Katsuhiko; Furukawa, Hiroyuki; Uemoto, Shinji; Maehara, Yoshihiko.
：: Clinical Transplantation, 巻 31, 番号 11, e13109, 01.11.2017.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Asunaprevir and daclatasvir for recurrent hepatitis C after liver transplantation
T2 - A Japanese multicenter experience
AU - Ikegami, Toru
AU - Ueda, Yoshihide
AU - Akamatsu, Nobuhisa
AU - Ishiyama, Kohei
AU - Goto, Ryoichi
AU - Soyama, Akihiko
AU - Kuramitsu, Kaori
AU - Honda, Masaki
AU - Shinoda, Masahiro
AU - Yoshizumi, Tomoharu
AU - Okajima, Hideaki
AU - Kitagawa, Yuko
AU - Inomata, Yukihiro
AU - Ku, Yonson
AU - Eguchi, Susumu
AU - Taketomi, Akinobu
AU - Ohdan, Hideki
AU - Kokudo, Norihiro
AU - Shimada, Mitsuo
AU - Yanaga, Katsuhiko
AU - Furukawa, Hiroyuki
AU - Uemoto, Shinji
AU - Maehara, Yoshihiko
PY - 2017/11/1
Y1 - 2017/11/1
N2 - The safety and efficacy of an IFN-free regimen using asunaprevir (ASV) and daclatasvir (DCV) for recurrent hepatitis C virus (HCV) infection after liver transplantation (LT) have not been evaluated in Japan. A multicenter study of LT recipients (n = 74) with recurrent HCV genotype 1b infection treated with ASV-DCV for 24 weeks was performed. Medical history was positive for pegylated interferon and ribavirin (Peg-IFN/RBV) in 40 (54.1%) patients, and for simeprevir (SMV) with Peg-IFN/RBV in 12 (16.2%) patients. Resistance-associated variants (RAVs) were positive at D168 (n = 1) in the NS3, and at L31 (n = 4), Y93 (n = 4), and L31/Y93 (n = 1) in the NS5A region of the HCV genome. Sixty-one (82.4%) patients completed the 24-week treatment protocol. Although sustained viral response (SVR) was achieved in 49 (80.3%) patients, it was achieved in only two (16.7%) patients among those with histories of receiving SMV (n = 12). Univariate analysis showed that a history of SMV (P <.01) and the presence of mutations in NS5A (P =.02) were the significant factors for no-SVR. By excluding the patients with either a history of SMV-based treatment or RAVs in NS3/NS5A, the SVR rate was 96.4%. By excluding the patients with a history of SMV and those with RAVs in NS3/NS5A, viral clearance of ASV-DCV was favorable, with a high SVR rate.
AB - The safety and efficacy of an IFN-free regimen using asunaprevir (ASV) and daclatasvir (DCV) for recurrent hepatitis C virus (HCV) infection after liver transplantation (LT) have not been evaluated in Japan. A multicenter study of LT recipients (n = 74) with recurrent HCV genotype 1b infection treated with ASV-DCV for 24 weeks was performed. Medical history was positive for pegylated interferon and ribavirin (Peg-IFN/RBV) in 40 (54.1%) patients, and for simeprevir (SMV) with Peg-IFN/RBV in 12 (16.2%) patients. Resistance-associated variants (RAVs) were positive at D168 (n = 1) in the NS3, and at L31 (n = 4), Y93 (n = 4), and L31/Y93 (n = 1) in the NS5A region of the HCV genome. Sixty-one (82.4%) patients completed the 24-week treatment protocol. Although sustained viral response (SVR) was achieved in 49 (80.3%) patients, it was achieved in only two (16.7%) patients among those with histories of receiving SMV (n = 12). Univariate analysis showed that a history of SMV (P <.01) and the presence of mutations in NS5A (P =.02) were the significant factors for no-SVR. By excluding the patients with either a history of SMV-based treatment or RAVs in NS3/NS5A, the SVR rate was 96.4%. By excluding the patients with a history of SMV and those with RAVs in NS3/NS5A, viral clearance of ASV-DCV was favorable, with a high SVR rate.
UR - http://www.scopus.com/inward/record.url?scp=85030242819&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85030242819&partnerID=8YFLogxK
U2 - 10.1111/ctr.13109
DO - 10.1111/ctr.13109
M3 - Article
C2 - 28881052
AN - SCOPUS:85030242819
VL - 31
JO - Clinical Transplantation
JF - Clinical Transplantation
SN - 0902-0063
IS - 11
M1 - e13109
ER -