Asymmetric Baylis-Hillman reactions using chiral 2,3-disubstituted 1,4-diazabicyclo[2.2.2]octanes catalysts under high pressure conditions

Tohru Oishi; Hiroki Oguri; Masahiro Hirama

doi:10.1016/0957-4166(95)00153-G

Asymmetric Baylis-Hillman reactions using chiral 2,3-disubstituted 1,4-diazabicyclo[2.2.2]octanes catalysts under high pressure conditions

Tohru Oishi, Hiroki Oguri, Masahiro Hirama

研究成果: Contribution to journal › Article › 査読

124 被引用数 (Scopus)

抄録

Chiral C₂-symmetric 2,3-disubstituted 1,4-diazabicyclo[2.2.2]octanes (DABCOs) (1) have been utilized as catalysts for asymmetric Baylis-Hillman reactions. Optically active α-methylene-β-hydroxyalkanone was obtained in up to 47% ee. Under high pressure conditions, a remarkable enhancement of both reaction rate and enantioselectivity has been observed.

本文言語	英語
ページ（範囲）	1241-1244
ページ数	4
ジャーナル	Tetrahedron: Asymmetry
巻	6
号	6
DOI	https://doi.org/10.1016/0957-4166(95)00153-G
出版ステータス	出版済み - 1 1 1995
外部発表	はい

All Science Journal Classification (ASJC) codes

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

文献へのアクセス

10.1016/0957-4166(95)00153-G

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引用スタイル

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abstract = "Chiral C2-symmetric 2,3-disubstituted 1,4-diazabicyclo[2.2.2]octanes (DABCOs) (1) have been utilized as catalysts for asymmetric Baylis-Hillman reactions. Optically active α-methylene-β-hydroxyalkanone was obtained in up to 47% ee. Under high pressure conditions, a remarkable enhancement of both reaction rate and enantioselectivity has been observed.",

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AU - Hirama, Masahiro

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