Asymmetric construction of binaphthyl by the chiral diether-mediated conjugate addition of naphthyllithium to naphthalenecarboxylic acid 2,6-di-t-butyl-4-methoxyphenyl ester

Mitsuru Shindo, Yasutomo Yamamoto, Ken Ichi Yamada, Kiyoshi Tomioka

研究成果: Contribution to journalArticle査読

7 被引用数 (Scopus)

抄録

Two ways for the synthesis of binaphthyl were examined based on a chiral ligand-mediated asymmetric conjugate addition of 1-naphthyllithium to naththalene-2-carboxylic acid 2,6-di-t-butyl-4-methoxyphenyl esters. The one pot method by conjugate addition-elimination gave a relatively higher enantioselectivity than the two step synthesis based on addition and subsequent oxidative aromatization.

本文言語英語
ページ(範囲)752-754
ページ数3
ジャーナルChemical and Pharmaceutical Bulletin
57
7
DOI
出版ステータス出版済み - 7 2009

All Science Journal Classification (ASJC) codes

  • 化学 (全般)
  • 創薬

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