Asymmetric Heck reaction

Masakatsu Shibasaki, Erasmus M. Vogl, Takashi Ohshima

研究成果: Contribution to journalReview article査読

294 被引用数 (Scopus)

抄録

The asymmetric Heck reaction is a powerful method for the synthesis of both tertiary and quaternary chiral carbon centers, with an enantiomeric excess often greater than 80%, and in some cases much higher (up to 99% ee). A variety of carbocyclic and heterocyclic systems can be constructed, including spirocyclic systems. The scope of the reaction with respect to the product alkene isomerization is somewhat limited by problems of regioselectivity, however, these problems are surmountable, and a new generation of ligands that dissociate more rapidly from the products, might improve both enantio- and regiocontrol. A variety of chiral compounds prepared by the asymmetric Heck reaction were successfully utilized in the enantioselective syntheses of complex natural products.

本文言語英語
ページ(範囲)1533-1552
ページ数20
ジャーナルAdvanced Synthesis and Catalysis
346
13-15
DOI
出版ステータス出版済み - 12 2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • 触媒
  • 有機化学

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