Asymmetric hydrogenation of aromatic carbocycles

Yusuke Makida, Ryoichi Kuwano

研究成果: Chapter in Book/Report/Conference proceedingChapter

抄録

The dearomative reduction of (hetero)aromatic compounds represents one of straightforward and attractive transformations for the construction of chiral cyclic compounds, which contain important structural motifs in a wide range of scientific disciplines. Stereoselective hydrogenation of carbocyclic arenes requires higher reaction temperature than that of heteroarenes because the benzene ring is highly stabilized with its inherent aromaticity. Considering the kinetic aspects of enantioselective transformations, high reaction temperature is generally unfavorable. To achieve high stereoselectivity, therefore, carefully and precisely designed chiral auxiliary or catalyst is particularly desirable. Herein, we will summarize two distinct approaches for the asymmetric hydrogenation of aromatic carbocycles: (1) through combinational use of chiral auxiliary and heterogeneous catalysis, (2) with chiral homogeneous metal complex as the catalyst.

本文言語英語
ホスト出版物のタイトルKinetic Control in Synthesis and Self-Assembly
出版社Elsevier
ページ97-108
ページ数12
ISBN(電子版)9780128121269
ISBN(印刷版)9780128121276
DOI
出版ステータス出版済み - 1 1 2018

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

フィンガープリント 「Asymmetric hydrogenation of aromatic carbocycles」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル