Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes

Yusuke Makida; Masahiro Saita; Takahiro Kuramoto; Kentaro Ishizuka; Ryoichi Kuwano

doi:10.1002/anie.201606083

Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes

Yusuke Makida, Masahiro Saita, Takahiro Kuramoto, Kentaro Ishizuka, Ryoichi Kuwano

複合領域化学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

16 被引用数 (Scopus)

抄録

High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η³-methallyl)₂(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.

本文言語	英語
ページ（範囲）	11859-11862
ページ数	4
ジャーナル	Angewandte Chemie - International Edition
巻	55
号	39
DOI	https://doi.org/10.1002/anie.201606083
出版ステータス	出版済み - 9月 19 2016

!!!All Science Journal Classification (ASJC) codes

触媒
化学 (全般)

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10.1002/anie.201606083

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引用スタイル

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abstract = "High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η3-methallyl)2(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.",

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AU - Kuwano, Ryoichi

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