Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes

Yusuke Makida; Masahiro Saita; Takahiro Kuramoto; Kentaro Ishizuka; Ryoichi Kuwano

doi:10.1002/anie.201606083

Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes

Yusuke Makida, Masahiro Saita, Takahiro Kuramoto, Kentaro Ishizuka, Ryoichi Kuwano

複合領域化学

研究成果: Contribution to journal › Article › 査読

9 被引用数 (Scopus)

抄録

High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η³-methallyl)₂(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.

本文言語	英語
ページ（範囲）	11859-11862
ページ数	4
ジャーナル	Angewandte Chemie - International Edition
巻	55
号	39
DOI	https://doi.org/10.1002/anie.201606083
出版ステータス	出版済み - 9 19 2016

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

文献へのアクセス

10.1002/anie.201606083

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引用スタイル

Asymmetric Hydrogenation of Azaindoles : Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes. / Makida, Yusuke; Saita, Masahiro; Kuramoto, Takahiro; Ishizuka, Kentaro; Kuwano, Ryoichi.

In: Angewandte Chemie - International Edition, Vol. 55, No. 39, 19.09.2016, p. 11859-11862.

研究成果: Contribution to journal › Article › 査読

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