Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes

Yusuke Makida, Masahiro Saita, Takahiro Kuramoto, Kentaro Ishizuka, Ryoichi Kuwano

研究成果: ジャーナルへの寄稿 › 記事

7 引用 (Scopus)

抄録

High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η3-methallyl)2(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.

元の言語英語
ページ（範囲）11859-11862
ページ数4
ジャーナルAngewandte Chemie - International Edition
巻55
発行部数39
DOI
出版物ステータス出版済み - 1 1 2016

Fingerprint

phosphine
Enantiomers
Enantioselectivity
Chelation
Hydrogenation
Ligands
Catalysts

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

これを引用

Asymmetric Hydrogenation of Azaindoles : Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes. / Makida, Yusuke; Saita, Masahiro; Kuramoto, Takahiro; Ishizuka, Kentaro; Kuwano, Ryoichi.

：: Angewandte Chemie - International Edition, 巻 55, 番号 39, 01.01.2016, p. 11859-11862.

研究成果: ジャーナルへの寄稿 › 記事

Makida, Y, Saita, M, Kuramoto, T, Ishizuka, K & Kuwano, R 2016, 'Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes', Angewandte Chemie - International Edition, 巻. 55, 番号 39, pp. 11859-11862. https://doi.org/10.1002/anie.201606083
Makida Y, Saita M, Kuramoto T, Ishizuka K, Kuwano R. Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes. Angewandte Chemie - International Edition. 2016 1 1;55(39):11859-11862. https://doi.org/10.1002/anie.201606083
Makida, Yusuke ; Saita, Masahiro ; Kuramoto, Takahiro ; Ishizuka, Kentaro ; Kuwano, Ryoichi. / Asymmetric Hydrogenation of Azaindoles : Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes. ：: Angewandte Chemie - International Edition. 2016 ; 巻 55, 番号 39. pp. 11859-11862.
@article{2329aa45f2f346e483b2078e0d10c72d,
title = "Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes",
abstract = "High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η3-methallyl)2(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.",
author = "Yusuke Makida and Masahiro Saita and Takahiro Kuramoto and Kentaro Ishizuka and Ryoichi Kuwano",
year = "2016",
month = "1",
day = "1",
doi = "10.1002/anie.201606083",
language = "English",
volume = "55",
pages = "11859--11862",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "39",

}

TY - JOUR

T1 - Asymmetric Hydrogenation of Azaindoles

T2 - Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes

AU - Makida, Yusuke

AU - Saita, Masahiro

AU - Kuramoto, Takahiro

AU - Ishizuka, Kentaro

AU - Kuwano, Ryoichi

PY - 2016/1/1

Y1 - 2016/1/1

N2 - High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η3-methallyl)2(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.

AB - High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η3-methallyl)2(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.

UR - http://www.scopus.com/inward/record.url?scp=84992013229&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992013229&partnerID=8YFLogxK

U2 - 10.1002/anie.201606083

DO - 10.1002/anie.201606083

M3 - Article

AN - SCOPUS:84992013229

VL - 55

SP - 11859

EP - 11862

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 39

ER -

文献にアクセス