TY - JOUR
T1 - Asymmetric Hydrogenation of Azaindoles
T2 - Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes
AU - Makida, Yusuke
AU - Saita, Masahiro
AU - Kuramoto, Takahiro
AU - Ishizuka, Kentaro
AU - Kuwano, Ryoichi
N1 - Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2016/9/19
Y1 - 2016/9/19
N2 - High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η3-methallyl)2(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.
AB - High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η3-methallyl)2(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.
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U2 - 10.1002/anie.201606083
DO - 10.1002/anie.201606083
M3 - Article
AN - SCOPUS:84992013229
VL - 55
SP - 11859
EP - 11862
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 39
ER -