Asymmetric hydrogenation of heteroaromatic ketones and cyclic and acyclic enones mediated by Cu(I)-chiral diphosphine catalysts

Hideo Shimizu, Takuto Nagano, Noboru Sayo, Takao Saito, Takashi Ohshima, Kazushi Mashima

研究成果: Contribution to journalArticle査読

41 被引用数 (Scopus)

抄録

Copper(I)-catalyzed asymmetric hydrogenation of heteroaromatic ketones, cyclic and acyclic enones is reported. The choice of the chiral diphosphine ligand highly influenced enantiose-lectivity as well as chemoselectivity. Highly enantioselective hydrogenation of ortho-substituted heteroaromatic ketones was achieved using BDPP as the ligand. In the 1,2-selective hydrogenation of acylic enone, SEGPHOS gave higher enantioselectivity than BDPP. On the other hand, the bulky ligand DTBM-SEGPHOS had a 1,4-selective nature, leading to the first highly 1,4-selective and enantioselective hydrogenation of cyclic enones.

本文言語英語
ページ(範囲)3143-3146
ページ数4
ジャーナルSynlett
19
DOI
出版ステータス出版済み - 12 21 2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • 有機化学

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