@article{fcb43e685cb3473a90af20668166854a,
title = "Asymmetric Synthesis of Axially Chiral Benzocarbazole Derivatives Based on Catalytic Enantioselective Hydroarylation of Alkynes",
abstract = "A new synthetic approach to novel axially chiral benzocarbazole derivatives based on the highly enantioselective intramolecular hydroarylation (94-96% ee) of linked alkyne-indole systems by using the prevalent chiral base catalyst, cinchonidine or cinchonine, under unprecedented transition-metal-free conditions is described. The process is considered to involve chiral base catalysis for enantioselective transformation of the alkyne part to a reaction intermediate with an axially chiral vinylidene o-quinone methide (VQM) functionality, which subsequently effects stereospecific cyclization with the tethered indole moiety.",
author = "Sachie Arae and Shota Beppu and Takahiro Kawatsu and Kazunobu Igawa and Katsuhiko Tomooka and Ryo Irie",
note = "Funding Information: This work was financially supported by a Grant-in-Aid for Scientific Research (C) (No. 24550059) from JSPS and a Grant-in-Aid for Scientific Research on Innovative Areas “Advanced Molecular Transformations by Organocatalysts” (No. 26105749) from MEXT. It was also performed under the Cooperative Research Program of “NJRC Mater. & Dev.” and the Research Program for CORE lab of “Five-star Alliance” in “NJRC Mater. & Dev.” Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",
year = "2018",
month = aug,
day = "17",
doi = "10.1021/acs.orglett.8b01945",
language = "English",
volume = "20",
pages = "4796--4800",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "16",
}