Asymmetric synthesis of multisubstituted dihydrobenzofurans by intramolecular conjugate addition of short-lived C-O axially chiral enolates

Keisuke Tomohara, Koji Kasamatsu, Tomoyuki Yoshimura, Takumi Furuta, Takeo Kawabata

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

Enantioselective intramolecular conjugate addition reactions of short-lived C-O axially chiral enolates have been developed. The reactions proceeded with inversion of the configuration and provided dihydrobenzofurans with contiguous tetra- and trisubstituted carbon centers in up to 96% enantiomeric excess (ee).

元の言語英語
ページ(範囲)899-906
ページ数8
ジャーナルChemical and Pharmaceutical Bulletin
64
発行部数7
DOI
出版物ステータス出版済み - 1 1 2016
外部発表Yes

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Addition reactions
Carbon

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

これを引用

Asymmetric synthesis of multisubstituted dihydrobenzofurans by intramolecular conjugate addition of short-lived C-O axially chiral enolates. / Tomohara, Keisuke; Kasamatsu, Koji; Yoshimura, Tomoyuki; Furuta, Takumi; Kawabata, Takeo.

:: Chemical and Pharmaceutical Bulletin, 巻 64, 番号 7, 01.01.2016, p. 899-906.

研究成果: ジャーナルへの寄稿記事

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abstract = "Enantioselective intramolecular conjugate addition reactions of short-lived C-O axially chiral enolates have been developed. The reactions proceeded with inversion of the configuration and provided dihydrobenzofurans with contiguous tetra- and trisubstituted carbon centers in up to 96{\%} enantiomeric excess (ee).",
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AU - Furuta, Takumi

AU - Kawabata, Takeo

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