Atorvastatin Promotes Phagocytosis and Attenuates Pro-Inflammatory Response in Human Retinal Pigment Epithelial Cells

Bo Tian, Ahmad Al-Moujahed, Peggy Bouzika, Yijun Hu, Shoji Notomi, Pavlina Tsoka, Joan W. Miller, Haijiang Lin, Demetrios G. Vavvas

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

抄録

Phagocytosis of daily shed photoreceptor outer segments is an important function of the retinal pigment epithelium (RPE) and it is essential for retinal homeostasis. RPE dysfunction, especially impairment of its phagocytic ability, plays an essential role in the pathogenesis of age-related macular degeneration (AMD). Statins, or HMG CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitors, are drugs with multiple properties that have been extensively used to treat hyperlipidemia. However, their effect on RPE cells has not been fully elucidated. Here we report that high dose atorvastatin increased the phagocytic function of ARPE-19 cells, as well as rescue the cells from the phagocytic dysfunction induced by cholesterol crystals and oxidized low-density lipoproteins (ox-LDL), potentially by increasing the cellular membrane fluidity. Similar effects were observed when evaluating two other hydrophobic statins, lovastatin and simvastatin. Furthermore, atorvastatin was able to block the induction of interleukins IL-6 and IL-8 triggered by pathologic stimuli relevant to AMD, such as cholesterol crystals and ox-LDL. Our study shows that statins, a well-Tolerated class of drugs with rare serious adverse effects, help preserve the phagocytic function of the RPE while also exhibiting anti-inflammatory properties. Both characteristics make statins a potential effective medication for the prevention and treatment of AMD.

元の言語英語
記事番号2329
ジャーナルScientific reports
7
発行部数1
DOI
出版物ステータス出版済み - 12 1 2017

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Retinal Pigments
Retinal Pigment Epithelium
Phagocytosis
Macular Degeneration
Epithelial Cells
Interleukin-6
Cholesterol
Lovastatin
Membrane Fluidity
Simvastatin
Phagocytes
Hyperlipidemias
Interleukin-8
Pharmaceutical Preparations
Oxidoreductases
Homeostasis
Anti-Inflammatory Agents
Atorvastatin Calcium
oxidized low density lipoprotein

All Science Journal Classification (ASJC) codes

  • General

これを引用

Atorvastatin Promotes Phagocytosis and Attenuates Pro-Inflammatory Response in Human Retinal Pigment Epithelial Cells. / Tian, Bo; Al-Moujahed, Ahmad; Bouzika, Peggy; Hu, Yijun; Notomi, Shoji; Tsoka, Pavlina; Miller, Joan W.; Lin, Haijiang; Vavvas, Demetrios G.

:: Scientific reports, 巻 7, 番号 1, 2329, 01.12.2017.

研究成果: ジャーナルへの寄稿記事

Tian, Bo ; Al-Moujahed, Ahmad ; Bouzika, Peggy ; Hu, Yijun ; Notomi, Shoji ; Tsoka, Pavlina ; Miller, Joan W. ; Lin, Haijiang ; Vavvas, Demetrios G. / Atorvastatin Promotes Phagocytosis and Attenuates Pro-Inflammatory Response in Human Retinal Pigment Epithelial Cells. :: Scientific reports. 2017 ; 巻 7, 番号 1.
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