ATP-activated single-channel currents recorded from cell-free patches of pheochromocytoma PC12 cells

Ken Nakazawa, Kazuhide Inoue, Kannosuke Fujimori, Akira Takanaka

研究成果: ジャーナルへの寄稿記事

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Single-channel recordings were made using cell-free membrane patches (outside-out configuration) isolated from pheochromocytoma PC12 cells. ATP (50 μM) activated single channel currents in the isolated patches and the currents inactivated with a half-decay time of about 5 s. The single channel conductance was about 13 pS in external solution with 140 mM Na. The amplitudes of the single-channel currents were decreased when external Ca was increased from 1.8 to 16.2 mM, suggesting that Ca blocks ion permeation through the channel. These properties of single-channel currents may underlie those of the macroscopic current.

元の言語英語
ページ(範囲)5-8
ページ数4
ジャーナルNeuroscience Letters
119
発行部数1
DOI
出版物ステータス出版済み - 10 30 1990
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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