ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Synaptic Purinoceptors: The Stage for ATP to Play Its "Dual-Role"

Fusao Kato, Masahito Kawamura, Eiji Shigetomi, Jun Ichi Tanaka, Kazuhide Inoue

研究成果: Contribution to journalArticle査読

24 被引用数 (Scopus)

抄録

The studies aiming to understand the function of purinoceptors in the central nervous system (CNS), which has been explored mostly in isolated and cultured cell systems, are now at the stage of identifying their physiological and pathophysiological significance in the native organs, tissues, and whole animals. The results of our recent studies made in brain slice preparations are not in full accordance with what have been demonstrated in isolated cells, mostly due to strong interplay between ATP receptors, adenosine receptors, and ecto-nucleotidases. This suggests that these proteins form coordinated regulation systems in the native tissue, controlling the local network behaviors through regulating the balance between the effects of ATP and adenosine on synaptic transmissions. We propose that this tripartite regulation system by extracellular purines may be an important target of CNS drugs.

本文言語英語
ページ(範囲)107-111
ページ数5
ジャーナルJournal of Pharmacological Sciences
94
2
DOI
出版ステータス出版済み - 2 2004

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 薬理学

フィンガープリント

「ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Synaptic Purinoceptors: The Stage for ATP to Play Its "Dual-Role"」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル