ATP receptors in the central nervous system

Kazuhide Inoue

研究成果: Contribution to journalReview article査読

1 被引用数 (Scopus)

抄録

ATP receptors in the central nervous system (CNS) are divided into 2 major classes, ionotropic (P2Xn) and G protein-coupled (P2Yn) ATP receptors. P2Xn receptors, a member of the 2-transmembrane family, contain non-selective cation channels that may play a role in rapid synaptic transmission. Seven subtypes of P2Xn were reported so far. Although all of these subtypes are distributed in the CNS, P2X4 and P2X6 are most abundantly and widely distributed. P2X3 is distributed only in trigeminal ganglia neurons as well as in small-diameter DRG neurons, suggesting their relation to pain. P2Yn receptors, a member of the 7-transmembrane superfamily, are coupled with G(q/11) to activate PLCβ. These receptors are thought to play an important role in the modulation of synaptic efficacy. Seven subtypes of P2Yn were reported so far. P2Y1, P2Y2, P2Y3 and P2Y4 are distributed in the CNS. Neither selective agonists nor antagonists to P2Xn and P2Yn are known.

本文言語英語
ページ(範囲)173-182
ページ数10
ジャーナルFolia Pharmacologica Japonica
110
4
DOI
出版ステータス出版済み - 1997
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学

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