ATP11A is a novel predictive marker for metachronous metastasis of colorectal cancer

Norikatsu Miyoshi, Hideshi Ishii, Koshi Mimori, Fumiaki Tanaka, Kennichi Nagai, Mamoru Uemura, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

研究成果: Contribution to journalArticle

10 引用 (Scopus)

抜粋

The adenosine triphosphate-binding cassette transporter-homologous gene ATP11A belongs to an extended family of adenosine triphosphate-binding cassette transporters. We analysed the ATP11A gene in 7 colorectal cancer cell lines and 95 paired cases of colorectal cancer and non-cancerous regions to demonstrate the importance of ATP11A expression in colorectal cancer prognosis. ATP11A was expressed in the 7 colorectal cancer cell lines. ATP11A mRNA expression was higher in colorectal cancer tissue than in corresponding normal tissue (P<0.001). Patients with high ATP11A expression showed a poorer disease-free survival rate compared to those with low expression (P<0.001), thus indicating that increase in ATP11A expression was an independent predictor of metachronous metastasis of colorectal cancer. The present study suggests that ATP11A is a useful predictive marker of metastasis in colorectal cancer patients.

元の言語英語
ページ(範囲)505-510
ページ数6
ジャーナルOncology reports
23
発行部数2
DOI
出版物ステータス出版済み - 2 2010

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

フィンガープリント ATP11A is a novel predictive marker for metachronous metastasis of colorectal cancer' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Miyoshi, N., Ishii, H., Mimori, K., Tanaka, F., Nagai, K., Uemura, M., Sekimoto, M., Doki, Y., & Mori, M. (2010). ATP11A is a novel predictive marker for metachronous metastasis of colorectal cancer. Oncology reports, 23(2), 505-510. https://doi.org/10.3892/or-00000662