Attachment and growth of fibroblast cells on poly (2-methoxyethyl acrylate) analog polymers as coating materials

Rubaiya Anjum, Kei Nishida, Haruka Matsumoto, Daiki Murakami, Shingo Kobayashi, Takahisa Anada, Masaru Tanaka

研究成果: Contribution to journalArticle査読

抄録

The regulation of adhesion and the subsequent behavior of fibroblast cells on the surface of biomaterials is important for successful tissue regeneration and wound healing by implanted biomaterials. We have synthesized poly(ω-methoxyalkyl acrylate)s (PMCxAs; x indicates the number of methylene carbons between the ester and ethyl oxygen), with a carbon chain length of x = 2–6, to investigate the regulation of fibroblast cell behavior including adhesion, proliferation, migration, differentiation and collagen production. We found that PMC2A suppressed the cell spreading, protein adsorption, formation of focal adhesion, and differentiation of normal human dermal fibroblasts, while PMC4A surfaces enhanced them compared to other PMCxAs. Our findings suggest that fibroblast activities attached to the PMCxA substrates can be modified by changing the number of methylene carbons in the side chains of the polymers. These results indicate that PMCxAs could be useful coating materials for use in skin regeneration and wound dressing applications.

本文言語英語
論文番号461
ジャーナルCoatings
11
4
DOI
出版ステータス出版済み - 4 2021

All Science Journal Classification (ASJC) codes

  • 表面および界面
  • 表面、皮膜および薄膜
  • 材料化学

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