Attenuated forearm vasodilative response to intra-arterial atrial natriuretic peptide in patients with heart failure

Yoshitaka Hirooka, A. Takeshita, T. Imaizumi, S. Suzuki, M. Yoshida, S. Ando, M. Nakamura

研究成果: ジャーナルへの寄稿記事

66 引用 (Scopus)

抄録

It has been shown that renal responses to atrial natriuretic peptide (ANP) are markedly attenuated in patients with heart failure. This study aimed to determine if vasodilative response to ANP is altered in patients with heart failure. In patients with heart failure (n = 7) and age-matched normal subjects (n = 7), forearm blood flow was measured using a strain-gauge plethysmograph during intra-arterial infusion of α-human ANP (50, 100, 200, and 400 ng/min) or nitroglycerin (100, 200, 400, and 600 ng/min). Forearm vasodilatation evoked with intra-arterial α-human ANP in patients with heart failure was considerably less (p < 0.01) than that in normal subjects. In contrast, nitroglycerin produced comparable forearm vasodilatation in the two groups. Plasma ANP and cyclic guanosine monophosphate (GMP) levels at rest were higher in patients with heart failure than in normal subjects (p < 0.05 for both), but the increases in plasma ANP and cyclic GMP in the venous effluents during intra-arterial ANP infusion did not differ between the two groups. These results indicate that the direct vasodilative effect of ANP on forearm vessels was attenuated in patients with heart failure as compared with that in normal subjects. The mechanisms responsible for this alteration are not clear but might involve mechanisms other than down-regulation of the ANP receptors because the increases in venous plasma cyclic GMP caused by intra-arterial ANP were comparable between patients with heart failure and normal subjects.

元の言語英語
ページ(範囲)147-153
ページ数7
ジャーナルCirculation
82
発行部数1
DOI
出版物ステータス出版済み - 1 1 1990

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Atrial Natriuretic Factor
Forearm
Heart Failure
Cyclic GMP
Nitroglycerin
Vasodilation
Atrial Natriuretic Factor Receptors
Intra Arterial Infusions
Down-Regulation
Kidney

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

これを引用

Hirooka, Y., Takeshita, A., Imaizumi, T., Suzuki, S., Yoshida, M., Ando, S., & Nakamura, M. (1990). Attenuated forearm vasodilative response to intra-arterial atrial natriuretic peptide in patients with heart failure. Circulation, 82(1), 147-153. https://doi.org/10.1161/01.CIR.82.1.147

Attenuated forearm vasodilative response to intra-arterial atrial natriuretic peptide in patients with heart failure. / Hirooka, Yoshitaka; Takeshita, A.; Imaizumi, T.; Suzuki, S.; Yoshida, M.; Ando, S.; Nakamura, M.

:: Circulation, 巻 82, 番号 1, 01.01.1990, p. 147-153.

研究成果: ジャーナルへの寄稿記事

Hirooka, Y, Takeshita, A, Imaizumi, T, Suzuki, S, Yoshida, M, Ando, S & Nakamura, M 1990, 'Attenuated forearm vasodilative response to intra-arterial atrial natriuretic peptide in patients with heart failure', Circulation, 巻. 82, 番号 1, pp. 147-153. https://doi.org/10.1161/01.CIR.82.1.147
Hirooka, Yoshitaka ; Takeshita, A. ; Imaizumi, T. ; Suzuki, S. ; Yoshida, M. ; Ando, S. ; Nakamura, M. / Attenuated forearm vasodilative response to intra-arterial atrial natriuretic peptide in patients with heart failure. :: Circulation. 1990 ; 巻 82, 番号 1. pp. 147-153.
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