抜粋
Multiple drug resistance (MDR) is a major clinical obstacle in cancer chemotherapy. Acquirement of MDR phenotype in cancer cells is often associated with enhanced expression of human MDR-1 gene: MDR-1 gene codes membranous P-glycoprotein which catalyses energy-dependent outward transport of anticancer agents. By contrast, MDR cancer cell lines without overexpression of P-glycoprotein are called as atypical MDR (at MDR) cells. The acquirement of at MDR has been shown to be partly associated with altered DNA topoisomerase II. Furthermore, a new ATP binding cassette (ABC) family, MRP gene has just recently shown to involve in acquirement of at-MDR in cancer cell lines, which do not express both altered topoisomerase II and P-glycoprotein.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 1123-1129 |
| ページ数 | 7 |
| ジャーナル | Japanese Journal of Cancer and Chemotherapy |
| 巻 | 21 |
| 発行部数 | 8 |
| 出版物ステータス | 出版済み - 1 1 1994 |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
フィンガープリント Atypical MDR' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。
これを引用
Yokomizo, A., Taniguchi, K., Hasegawa, S., Abe, T., Kubo, T., Makino, Y., Wada, M., Kohno, K., & Kuwano, M. (1994). Atypical MDR. Japanese Journal of Cancer and Chemotherapy, 21(8), 1123-1129.