Atypical MDR

A. Yokomizo, K. Taniguchi, S. Hasegawa, T. Abe, T. Kubo, Y. Makino, M. Wada, K. Kohno, M. Kuwano

研究成果: Contribution to journalReview article


Multiple drug resistance (MDR) is a major clinical obstacle in cancer chemotherapy. Acquirement of MDR phenotype in cancer cells is often associated with enhanced expression of human MDR-1 gene: MDR-1 gene codes membranous P-glycoprotein which catalyses energy-dependent outward transport of anticancer agents. By contrast, MDR cancer cell lines without overexpression of P-glycoprotein are called as atypical MDR (at MDR) cells. The acquirement of at MDR has been shown to be partly associated with altered DNA topoisomerase II. Furthermore, a new ATP binding cassette (ABC) family, MRP gene has just recently shown to involve in acquirement of at-MDR in cancer cell lines, which do not express both altered topoisomerase II and P-glycoprotein.

ジャーナルJapanese Journal of Cancer and Chemotherapy
出版物ステータス出版済み - 1 1 1994

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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  • これを引用

    Yokomizo, A., Taniguchi, K., Hasegawa, S., Abe, T., Kubo, T., Makino, Y., Wada, M., Kohno, K., & Kuwano, M. (1994). Atypical MDR. Japanese Journal of Cancer and Chemotherapy, 21(8), 1123-1129.