抄録
Multiple drug resistance (MDR) is a major clinical obstacle in cancer chemotherapy. Acquirement of MDR phenotype in cancer cells is often associated with enhanced expression of human MDR-1 gene: MDR-1 gene codes membranous P-glycoprotein which catalyses energy-dependent outward transport of anticancer agents. By contrast, MDR cancer cell lines without overexpression of P-glycoprotein are called as atypical MDR (at MDR) cells. The acquirement of at MDR has been shown to be partly associated with altered DNA topoisomerase II. Furthermore, a new ATP binding cassette (ABC) family, MRP gene has just recently shown to involve in acquirement of at-MDR in cancer cell lines, which do not express both altered topoisomerase II and P-glycoprotein.
本文言語 | 英語 |
---|---|
ページ(範囲) | 1123-1129 |
ページ数 | 7 |
ジャーナル | Japanese Journal of Cancer and Chemotherapy |
巻 | 21 |
号 | 8 |
出版ステータス | 出版済み - 1月 1 1994 |
!!!All Science Journal Classification (ASJC) codes
- 腫瘍学
- 癌研究