Augmentation of pulmonary vein backflow velocity during left atrial contraction

A novel phenomenon responsible for progression of atrial fibrillation in hypertensive patients

Toru Maruyama, Toshisuke Kishikawa, Hiroyuki Ito, Yoshikazu Kaji, Yasushi Sasaki, Yasushi Ishihara

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

抄録

Background: Atrial fibrillation (AF) is a common arrhythmia showing disease progression. However, echocardiographic prediction of such progression remains incomplete. This study aimed to identify echocardiographic predictors of AF progression in hypertensive patients. Methods: Hypertensive patients with paroxysmal AF were divided into two groups: patients with AF which became permanent (group A; n = 13) and those with AF which remained paroxysmal (group B; n = 46) during the same follow-up period (8.0 ± 2.4 years). Clinical baselines showed no significant differences except for age. Transthoracic echocardiography was recorded 1-2 weeks after termination of the first-detected paroxysms of AF. Results: Echocardiography showed greater left atrial (LA) dimension (p = 0.023) and late diastolic pulmonary vein (PV) backflow velocity (p < 0.001), and a lower LA fractional shortening (p = 0.008) in group A than in group B. Multilogistic regression analysis demonstrated that augmented PV backflow (p = 0.007) and reduced LA fractional shortening (p = 0.032) were independent predictors of the progression of AF. The receiver-operating characteristic curve demonstrated that PV backflow augmentation is the best predictor of future AF perpetuation. Conclusion: PV backflow leading to cyclic stretching of PV musculature contributes to AF progression.

元の言語英語
ページ(範囲)33-40
ページ数8
ジャーナルCardiology
109
発行部数1
DOI
出版物ステータス出版済み - 12 1 2007

Fingerprint

Pulmonary Veins
Atrial Fibrillation
Echocardiography
ROC Curve
Disease Progression
Cardiac Arrhythmias
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

これを引用

Augmentation of pulmonary vein backflow velocity during left atrial contraction : A novel phenomenon responsible for progression of atrial fibrillation in hypertensive patients. / Maruyama, Toru; Kishikawa, Toshisuke; Ito, Hiroyuki; Kaji, Yoshikazu; Sasaki, Yasushi; Ishihara, Yasushi.

:: Cardiology, 巻 109, 番号 1, 01.12.2007, p. 33-40.

研究成果: ジャーナルへの寄稿記事

Maruyama, Toru ; Kishikawa, Toshisuke ; Ito, Hiroyuki ; Kaji, Yoshikazu ; Sasaki, Yasushi ; Ishihara, Yasushi. / Augmentation of pulmonary vein backflow velocity during left atrial contraction : A novel phenomenon responsible for progression of atrial fibrillation in hypertensive patients. :: Cardiology. 2007 ; 巻 109, 番号 1. pp. 33-40.
@article{4c95ecca9d3d428a9e8c0d502930df91,
title = "Augmentation of pulmonary vein backflow velocity during left atrial contraction: A novel phenomenon responsible for progression of atrial fibrillation in hypertensive patients",
abstract = "Background: Atrial fibrillation (AF) is a common arrhythmia showing disease progression. However, echocardiographic prediction of such progression remains incomplete. This study aimed to identify echocardiographic predictors of AF progression in hypertensive patients. Methods: Hypertensive patients with paroxysmal AF were divided into two groups: patients with AF which became permanent (group A; n = 13) and those with AF which remained paroxysmal (group B; n = 46) during the same follow-up period (8.0 ± 2.4 years). Clinical baselines showed no significant differences except for age. Transthoracic echocardiography was recorded 1-2 weeks after termination of the first-detected paroxysms of AF. Results: Echocardiography showed greater left atrial (LA) dimension (p = 0.023) and late diastolic pulmonary vein (PV) backflow velocity (p < 0.001), and a lower LA fractional shortening (p = 0.008) in group A than in group B. Multilogistic regression analysis demonstrated that augmented PV backflow (p = 0.007) and reduced LA fractional shortening (p = 0.032) were independent predictors of the progression of AF. The receiver-operating characteristic curve demonstrated that PV backflow augmentation is the best predictor of future AF perpetuation. Conclusion: PV backflow leading to cyclic stretching of PV musculature contributes to AF progression.",
author = "Toru Maruyama and Toshisuke Kishikawa and Hiroyuki Ito and Yoshikazu Kaji and Yasushi Sasaki and Yasushi Ishihara",
year = "2007",
month = "12",
day = "1",
doi = "10.1159/000105324",
language = "English",
volume = "109",
pages = "33--40",
journal = "Cardiology",
issn = "0008-6312",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Augmentation of pulmonary vein backflow velocity during left atrial contraction

T2 - A novel phenomenon responsible for progression of atrial fibrillation in hypertensive patients

AU - Maruyama, Toru

AU - Kishikawa, Toshisuke

AU - Ito, Hiroyuki

AU - Kaji, Yoshikazu

AU - Sasaki, Yasushi

AU - Ishihara, Yasushi

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Background: Atrial fibrillation (AF) is a common arrhythmia showing disease progression. However, echocardiographic prediction of such progression remains incomplete. This study aimed to identify echocardiographic predictors of AF progression in hypertensive patients. Methods: Hypertensive patients with paroxysmal AF were divided into two groups: patients with AF which became permanent (group A; n = 13) and those with AF which remained paroxysmal (group B; n = 46) during the same follow-up period (8.0 ± 2.4 years). Clinical baselines showed no significant differences except for age. Transthoracic echocardiography was recorded 1-2 weeks after termination of the first-detected paroxysms of AF. Results: Echocardiography showed greater left atrial (LA) dimension (p = 0.023) and late diastolic pulmonary vein (PV) backflow velocity (p < 0.001), and a lower LA fractional shortening (p = 0.008) in group A than in group B. Multilogistic regression analysis demonstrated that augmented PV backflow (p = 0.007) and reduced LA fractional shortening (p = 0.032) were independent predictors of the progression of AF. The receiver-operating characteristic curve demonstrated that PV backflow augmentation is the best predictor of future AF perpetuation. Conclusion: PV backflow leading to cyclic stretching of PV musculature contributes to AF progression.

AB - Background: Atrial fibrillation (AF) is a common arrhythmia showing disease progression. However, echocardiographic prediction of such progression remains incomplete. This study aimed to identify echocardiographic predictors of AF progression in hypertensive patients. Methods: Hypertensive patients with paroxysmal AF were divided into two groups: patients with AF which became permanent (group A; n = 13) and those with AF which remained paroxysmal (group B; n = 46) during the same follow-up period (8.0 ± 2.4 years). Clinical baselines showed no significant differences except for age. Transthoracic echocardiography was recorded 1-2 weeks after termination of the first-detected paroxysms of AF. Results: Echocardiography showed greater left atrial (LA) dimension (p = 0.023) and late diastolic pulmonary vein (PV) backflow velocity (p < 0.001), and a lower LA fractional shortening (p = 0.008) in group A than in group B. Multilogistic regression analysis demonstrated that augmented PV backflow (p = 0.007) and reduced LA fractional shortening (p = 0.032) were independent predictors of the progression of AF. The receiver-operating characteristic curve demonstrated that PV backflow augmentation is the best predictor of future AF perpetuation. Conclusion: PV backflow leading to cyclic stretching of PV musculature contributes to AF progression.

UR - http://www.scopus.com/inward/record.url?scp=36949022694&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36949022694&partnerID=8YFLogxK

U2 - 10.1159/000105324

DO - 10.1159/000105324

M3 - Article

VL - 109

SP - 33

EP - 40

JO - Cardiology

JF - Cardiology

SN - 0008-6312

IS - 1

ER -