Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells

Yojiro Arinobu, Rie Sugimoto, Mina Akaiwa, Kazuhiko Arima, Takeshi Otsuka, Naotaka Hamasaki, Kenji Izuhara

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

抄録

Signal transducer and activation of transcription (STAT)6 has a central role in the signal transduction of interleukin (IL)-4 and IL-13. It has recently been revealed that STAT3 is also involved. STAT6 and STAT3 are expressed ubiquitously; however, it remains unknown how STAT6 and STAT3 expression is regulated. In this study, we found that STAT6 expression was augmented at the transcription level in B and T cells stimulated with anti-IgM antibody and anti-CD40 antibody or PMA and ionomycin, respectively, and that STAT3 expression was similarly augmented in the stimulated B cells. The stimulated B and T cells showed enhancement of STAT6 activation and CD23 expression induced by IL-4 and IL-13. Augmentation of STAT6 and STAT3 would be a mechanism of the amplification of the IL-4 and IL-13 signals in stimulated B and T cells. (C) 2000 Academic Press.

元の言語英語
ページ(範囲)317-324
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
277
発行部数2
DOI
出版物ステータス出版済み - 10 22 2000

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T-cells
Interleukin-13
Transcription
Transducers
Interleukin-4
Transcriptional Activation
B-Lymphocytes
Chemical activation
T-Lymphocytes
Anti-Idiotypic Antibodies
Signal transduction
Ionomycin
Amplification
Cells
Signal Transduction
Antibodies

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

これを引用

Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells. / Arinobu, Yojiro; Sugimoto, Rie; Akaiwa, Mina; Arima, Kazuhiko; Otsuka, Takeshi; Hamasaki, Naotaka; Izuhara, Kenji.

:: Biochemical and Biophysical Research Communications, 巻 277, 番号 2, 22.10.2000, p. 317-324.

研究成果: ジャーナルへの寄稿記事

Arinobu, Yojiro ; Sugimoto, Rie ; Akaiwa, Mina ; Arima, Kazuhiko ; Otsuka, Takeshi ; Hamasaki, Naotaka ; Izuhara, Kenji. / Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells. :: Biochemical and Biophysical Research Communications. 2000 ; 巻 277, 番号 2. pp. 317-324.
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AU - Arinobu, Yojiro

AU - Sugimoto, Rie

AU - Akaiwa, Mina

AU - Arima, Kazuhiko

AU - Otsuka, Takeshi

AU - Hamasaki, Naotaka

AU - Izuhara, Kenji

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AB - Signal transducer and activation of transcription (STAT)6 has a central role in the signal transduction of interleukin (IL)-4 and IL-13. It has recently been revealed that STAT3 is also involved. STAT6 and STAT3 are expressed ubiquitously; however, it remains unknown how STAT6 and STAT3 expression is regulated. In this study, we found that STAT6 expression was augmented at the transcription level in B and T cells stimulated with anti-IgM antibody and anti-CD40 antibody or PMA and ionomycin, respectively, and that STAT3 expression was similarly augmented in the stimulated B cells. The stimulated B and T cells showed enhancement of STAT6 activation and CD23 expression induced by IL-4 and IL-13. Augmentation of STAT6 and STAT3 would be a mechanism of the amplification of the IL-4 and IL-13 signals in stimulated B and T cells. (C) 2000 Academic Press.

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