Augmented excretion of procathepsin L of a fos-transferred highly metastatic rat cell line

Shun'ichiro Taniguchi, Yukio Nishimura, Takeshi Takahashi, Tsuneo Baba, Keitaro Kato

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)

抄録

We previously reported that v-fos transfer to a src-transformed rat 3Y1 cell line (SR-3Y1-2) enhanced lung metastasis accompanied with an increase in invasiveness. When analyzing factors relating to the high invasiveness, with special reference to typical lysosomal proteases (cathepsins), involving degradation of stroma, we found that the excretion of procathepsin L was significantly larger in the fos-transferred highly metastatic cell line (fos-SR-3Y1-202) than that in the recipient cell lines. The cathepsin D-induced enzyme activity of the excreted procathepsin L in fos-SR-3Y1-202 was about 4 and 13 fold that of SR-3Y1-2 and 3Y1, respectively. The increase in the excretion of procathepsin L from fos-SR-3Y1-202 may play a role in the high invasiveness induced by transfer with the v-fos oncogene.

元の言語英語
ページ(範囲)520-526
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
168
発行部数2
DOI
出版物ステータス出版済み - 4 30 1990

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Rats
Cells
4 alpha-glucanotransferase
Cell Line
fos Genes
Cathepsins
Cathepsin D
Enzyme activity
Peptide Hydrolases
Neoplasm Metastasis
Degradation
Lung
mifobate
procathepsin L

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

これを引用

Augmented excretion of procathepsin L of a fos-transferred highly metastatic rat cell line. / Taniguchi, Shun'ichiro; Nishimura, Yukio; Takahashi, Takeshi; Baba, Tsuneo; Kato, Keitaro.

:: Biochemical and Biophysical Research Communications, 巻 168, 番号 2, 30.04.1990, p. 520-526.

研究成果: ジャーナルへの寄稿記事

Taniguchi, Shun'ichiro ; Nishimura, Yukio ; Takahashi, Takeshi ; Baba, Tsuneo ; Kato, Keitaro. / Augmented excretion of procathepsin L of a fos-transferred highly metastatic rat cell line. :: Biochemical and Biophysical Research Communications. 1990 ; 巻 168, 番号 2. pp. 520-526.
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