AUGMENTED EXPRESSION OF THE ENDOTHELIN‐A RECEPTOR GENE IN CULTURED MESANGIAL CELLS FROM STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS

Junko Hiraoka, Hiroshi Arai, Takaaki Yoshimasa, Kazuhiko Takaya, Yoshihiro Miyamoto, Jun Yamashita, Shin‐ichi ‐i Suga, Yoshihiro Ogawa, Gotaro Shirakami, Hiroshi Itoh, Yukio Yamori, Kazuwa Nakao

研究成果: ジャーナルへの寄稿学術誌査読

2 被引用数 (Scopus)

抄録

1. To elucidate the role of endothelin (ET) receptor in hypertension, we studied the expression of the ET‐A receptor (ET‐ AR) gene and the ET‐B receptor (ET‐BR) gene in cultured mesangial cells isolated from stroke‐prone spontaneously hypertensive rats (SHRSP) and Wistar‐Kyoto (WKY) rats. 2. The mesangial cells from both SHRSP and WKY expressed ET‐AR predominantly. The level of the ET‐AR mRNA in mesangial cells from SHRSP was 5‐fold higher than that in the cells from WKY. The ET‐BR mRNA in the mesangial cells from both strains was hardly detectable by northern blot analysis. 3. These results demonstrate that the expression of the ET‐AR gene was markedly augmented in mesangial cells from SHRSP.

本文言語英語
ページ(範囲)S191-S192
ジャーナルClinical and Experimental Pharmacology and Physiology
22
DOI
出版ステータス出版済み - 11月 1995
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生理学
  • 薬理学
  • 生理学(医学)

フィンガープリント

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