Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis

Minoru Nakamura, Hisayoshi Kondo, Atsushi Tanaka, Atsumasa Komori, Masahiro Ito, Kazuhide Yamamoto, Hiromasa Ohira, Mikio Zeniya, Etsuko Hashimoto, Masao Honda, Shuichi Kaneko, Yoshiyuki Ueno, Kentaro Kikuchi, Shinji Shimoda, Kenichi Harada, Kuniaki Arai, Yasuhiro Miyake, Masanori Abe, Makiko Taniai, Toshiji SaibaraShotaro Sakisaka, Hajime Takikawa, Morikazu Onji, Hirohito Tsubouchi, Yasuni Nakanuma, Hiromi Ishibashi

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

抄録

Aim: The aim of the present study is to evaluate the factors influencing biochemical response to treatment and the value of biochemical response for predicting long-term outcomes in Japanese patients with primary biliary cirrhosis (PBC). Methods: Biochemical response to ursodeoxycholic acid (UDCA) or UDCA plus bezafibrate was defined as good (≤upper limit of normal [ULN]), fair (≤1.5×ULN) or poor (>1.5×ULN) at 2 years after initiation of UDCA treatment. Associations between various factors (including age, sex, autoantibody status and histological variables at baseline), biochemical response to treatment and long-term outcomes were evaluated in 164 Japanese PBC patients. Results: Anti-gp210 positivity and a higher bile duct loss score were significant risk factors for worse alkaline phosphatase (ALP) response (odds ratios [OR], 2.78 and 1.85, respectively). Age, anti-gp210 positivity and anticentromere positivity were significant risk factors for worse alanine aminotransferase (ALT) response (OR, 1.05, 4.0 and 2.77, respectively). Anti-gp210 positivity and a higher hepatitis score were significant risk factors for worse immunoglobulin (Ig)M response (OR, 2.10 and 2.06, respectively). Worse ALP and IgM response were significant risk factors for progression to late-stage disease without jaundice (OR, 2.27 and 2.32, respectively). Worse ALT response was a significant risk factor for progression to late-stage disease with persistent jaundice (OR, 11.11). Conclusion: Biochemical response to treatment at 2 years, which is influenced by autoantibody status and histological variables at baseline, can predict long-term outcomes in Japanese patients with PBC.

元の言語英語
ページ(範囲)846-855
ページ数10
ジャーナルHepatology Research
45
発行部数8
DOI
出版物ステータス出版済み - 8 1 2015

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Biliary Liver Cirrhosis
Autoantibodies
Ursodeoxycholic Acid
Odds Ratio
Jaundice
Alanine Transaminase
Alkaline Phosphatase
Immunoglobulin M
Bezafibrate
Therapeutics
Age Factors
Bile Ducts
Hepatitis

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Infectious Diseases

これを引用

Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis. / Nakamura, Minoru; Kondo, Hisayoshi; Tanaka, Atsushi; Komori, Atsumasa; Ito, Masahiro; Yamamoto, Kazuhide; Ohira, Hiromasa; Zeniya, Mikio; Hashimoto, Etsuko; Honda, Masao; Kaneko, Shuichi; Ueno, Yoshiyuki; Kikuchi, Kentaro; Shimoda, Shinji; Harada, Kenichi; Arai, Kuniaki; Miyake, Yasuhiro; Abe, Masanori; Taniai, Makiko; Saibara, Toshiji; Sakisaka, Shotaro; Takikawa, Hajime; Onji, Morikazu; Tsubouchi, Hirohito; Nakanuma, Yasuni; Ishibashi, Hiromi.

:: Hepatology Research, 巻 45, 番号 8, 01.08.2015, p. 846-855.

研究成果: ジャーナルへの寄稿記事

Nakamura, M, Kondo, H, Tanaka, A, Komori, A, Ito, M, Yamamoto, K, Ohira, H, Zeniya, M, Hashimoto, E, Honda, M, Kaneko, S, Ueno, Y, Kikuchi, K, Shimoda, S, Harada, K, Arai, K, Miyake, Y, Abe, M, Taniai, M, Saibara, T, Sakisaka, S, Takikawa, H, Onji, M, Tsubouchi, H, Nakanuma, Y & Ishibashi, H 2015, 'Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis', Hepatology Research, 巻. 45, 番号 8, pp. 846-855. https://doi.org/10.1111/hepr.12423
Nakamura, Minoru ; Kondo, Hisayoshi ; Tanaka, Atsushi ; Komori, Atsumasa ; Ito, Masahiro ; Yamamoto, Kazuhide ; Ohira, Hiromasa ; Zeniya, Mikio ; Hashimoto, Etsuko ; Honda, Masao ; Kaneko, Shuichi ; Ueno, Yoshiyuki ; Kikuchi, Kentaro ; Shimoda, Shinji ; Harada, Kenichi ; Arai, Kuniaki ; Miyake, Yasuhiro ; Abe, Masanori ; Taniai, Makiko ; Saibara, Toshiji ; Sakisaka, Shotaro ; Takikawa, Hajime ; Onji, Morikazu ; Tsubouchi, Hirohito ; Nakanuma, Yasuni ; Ishibashi, Hiromi. / Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis. :: Hepatology Research. 2015 ; 巻 45, 番号 8. pp. 846-855.
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title = "Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis",
abstract = "Aim: The aim of the present study is to evaluate the factors influencing biochemical response to treatment and the value of biochemical response for predicting long-term outcomes in Japanese patients with primary biliary cirrhosis (PBC). Methods: Biochemical response to ursodeoxycholic acid (UDCA) or UDCA plus bezafibrate was defined as good (≤upper limit of normal [ULN]), fair (≤1.5×ULN) or poor (>1.5×ULN) at 2 years after initiation of UDCA treatment. Associations between various factors (including age, sex, autoantibody status and histological variables at baseline), biochemical response to treatment and long-term outcomes were evaluated in 164 Japanese PBC patients. Results: Anti-gp210 positivity and a higher bile duct loss score were significant risk factors for worse alkaline phosphatase (ALP) response (odds ratios [OR], 2.78 and 1.85, respectively). Age, anti-gp210 positivity and anticentromere positivity were significant risk factors for worse alanine aminotransferase (ALT) response (OR, 1.05, 4.0 and 2.77, respectively). Anti-gp210 positivity and a higher hepatitis score were significant risk factors for worse immunoglobulin (Ig)M response (OR, 2.10 and 2.06, respectively). Worse ALP and IgM response were significant risk factors for progression to late-stage disease without jaundice (OR, 2.27 and 2.32, respectively). Worse ALT response was a significant risk factor for progression to late-stage disease with persistent jaundice (OR, 11.11). Conclusion: Biochemical response to treatment at 2 years, which is influenced by autoantibody status and histological variables at baseline, can predict long-term outcomes in Japanese patients with PBC.",
author = "Minoru Nakamura and Hisayoshi Kondo and Atsushi Tanaka and Atsumasa Komori and Masahiro Ito and Kazuhide Yamamoto and Hiromasa Ohira and Mikio Zeniya and Etsuko Hashimoto and Masao Honda and Shuichi Kaneko and Yoshiyuki Ueno and Kentaro Kikuchi and Shinji Shimoda and Kenichi Harada and Kuniaki Arai and Yasuhiro Miyake and Masanori Abe and Makiko Taniai and Toshiji Saibara and Shotaro Sakisaka and Hajime Takikawa and Morikazu Onji and Hirohito Tsubouchi and Yasuni Nakanuma and Hiromi Ishibashi",
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TY - JOUR

T1 - Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis

AU - Nakamura, Minoru

AU - Kondo, Hisayoshi

AU - Tanaka, Atsushi

AU - Komori, Atsumasa

AU - Ito, Masahiro

AU - Yamamoto, Kazuhide

AU - Ohira, Hiromasa

AU - Zeniya, Mikio

AU - Hashimoto, Etsuko

AU - Honda, Masao

AU - Kaneko, Shuichi

AU - Ueno, Yoshiyuki

AU - Kikuchi, Kentaro

AU - Shimoda, Shinji

AU - Harada, Kenichi

AU - Arai, Kuniaki

AU - Miyake, Yasuhiro

AU - Abe, Masanori

AU - Taniai, Makiko

AU - Saibara, Toshiji

AU - Sakisaka, Shotaro

AU - Takikawa, Hajime

AU - Onji, Morikazu

AU - Tsubouchi, Hirohito

AU - Nakanuma, Yasuni

AU - Ishibashi, Hiromi

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Aim: The aim of the present study is to evaluate the factors influencing biochemical response to treatment and the value of biochemical response for predicting long-term outcomes in Japanese patients with primary biliary cirrhosis (PBC). Methods: Biochemical response to ursodeoxycholic acid (UDCA) or UDCA plus bezafibrate was defined as good (≤upper limit of normal [ULN]), fair (≤1.5×ULN) or poor (>1.5×ULN) at 2 years after initiation of UDCA treatment. Associations between various factors (including age, sex, autoantibody status and histological variables at baseline), biochemical response to treatment and long-term outcomes were evaluated in 164 Japanese PBC patients. Results: Anti-gp210 positivity and a higher bile duct loss score were significant risk factors for worse alkaline phosphatase (ALP) response (odds ratios [OR], 2.78 and 1.85, respectively). Age, anti-gp210 positivity and anticentromere positivity were significant risk factors for worse alanine aminotransferase (ALT) response (OR, 1.05, 4.0 and 2.77, respectively). Anti-gp210 positivity and a higher hepatitis score were significant risk factors for worse immunoglobulin (Ig)M response (OR, 2.10 and 2.06, respectively). Worse ALP and IgM response were significant risk factors for progression to late-stage disease without jaundice (OR, 2.27 and 2.32, respectively). Worse ALT response was a significant risk factor for progression to late-stage disease with persistent jaundice (OR, 11.11). Conclusion: Biochemical response to treatment at 2 years, which is influenced by autoantibody status and histological variables at baseline, can predict long-term outcomes in Japanese patients with PBC.

AB - Aim: The aim of the present study is to evaluate the factors influencing biochemical response to treatment and the value of biochemical response for predicting long-term outcomes in Japanese patients with primary biliary cirrhosis (PBC). Methods: Biochemical response to ursodeoxycholic acid (UDCA) or UDCA plus bezafibrate was defined as good (≤upper limit of normal [ULN]), fair (≤1.5×ULN) or poor (>1.5×ULN) at 2 years after initiation of UDCA treatment. Associations between various factors (including age, sex, autoantibody status and histological variables at baseline), biochemical response to treatment and long-term outcomes were evaluated in 164 Japanese PBC patients. Results: Anti-gp210 positivity and a higher bile duct loss score were significant risk factors for worse alkaline phosphatase (ALP) response (odds ratios [OR], 2.78 and 1.85, respectively). Age, anti-gp210 positivity and anticentromere positivity were significant risk factors for worse alanine aminotransferase (ALT) response (OR, 1.05, 4.0 and 2.77, respectively). Anti-gp210 positivity and a higher hepatitis score were significant risk factors for worse immunoglobulin (Ig)M response (OR, 2.10 and 2.06, respectively). Worse ALP and IgM response were significant risk factors for progression to late-stage disease without jaundice (OR, 2.27 and 2.32, respectively). Worse ALT response was a significant risk factor for progression to late-stage disease with persistent jaundice (OR, 11.11). Conclusion: Biochemical response to treatment at 2 years, which is influenced by autoantibody status and histological variables at baseline, can predict long-term outcomes in Japanese patients with PBC.

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DO - 10.1111/hepr.12423

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