Autoimmune blistering disease with concurrent IgG antibodies to desmoglein 1 and BP180: Two cases

Miki Ichikawa, Maya Tanaka, Kazunori Urabe, Masutaka Furue

研究成果: ジャーナルへの寄稿記事

抄録

We report two cases with concurrent detection of antibodies to Desmoglein 1 and BP180. In Case 1, a 78-year-old man was diagnosed with bullous pemphigoid and had been treated with oral prednisolone for 2 years. He developed crusted erythema on his face and trunk despite the well-controlled state of his bullous pemphigoid. Direct immunofluorescence detected intracellular deposition of IgG in the epidermis, and anti-BP180 and anti-Dsg 1 antibodies were detected byenzy melinked immunosorbent assay. In Case 2, a 91-year-old woman had had pruritic erythema with crusting on her thighs, axillae, face, and back for 2 months. Treatment with topical steroids was ineffective, and edematous erythema and tense bullae developed on her lower limbs. Direct immunofluorescence detected linear deposition of IgG and C3 along the basement membrane zone. Anti-BP180 and anti-Dsg 1 antibodies were also detected by enzyme-linked immunosorbent assay.

元の言語英語
ページ(範囲)415-418
ページ数4
ジャーナルNishinihon Journal of Dermatology
75
発行部数5
DOI
出版物ステータス出版済み - 1 1 2013

Fingerprint

Desmoglein 1
Erythema
Autoimmune Diseases
Bullous Pemphigoid
Direct Fluorescent Antibody Technique
Immunoglobulin G
Antibodies
Immunosorbents
Axilla
Blister
Prednisolone
Thigh
Basement Membrane
Epidermis
Lower Extremity
Enzyme-Linked Immunosorbent Assay
Steroids
Therapeutics

All Science Journal Classification (ASJC) codes

  • Dermatology

これを引用

Autoimmune blistering disease with concurrent IgG antibodies to desmoglein 1 and BP180 : Two cases. / Ichikawa, Miki; Tanaka, Maya; Urabe, Kazunori; Furue, Masutaka.

:: Nishinihon Journal of Dermatology, 巻 75, 番号 5, 01.01.2013, p. 415-418.

研究成果: ジャーナルへの寄稿記事

@article{92987f974a434869a4b7a4d2ae14a3f6,
title = "Autoimmune blistering disease with concurrent IgG antibodies to desmoglein 1 and BP180: Two cases",
abstract = "We report two cases with concurrent detection of antibodies to Desmoglein 1 and BP180. In Case 1, a 78-year-old man was diagnosed with bullous pemphigoid and had been treated with oral prednisolone for 2 years. He developed crusted erythema on his face and trunk despite the well-controlled state of his bullous pemphigoid. Direct immunofluorescence detected intracellular deposition of IgG in the epidermis, and anti-BP180 and anti-Dsg 1 antibodies were detected byenzy melinked immunosorbent assay. In Case 2, a 91-year-old woman had had pruritic erythema with crusting on her thighs, axillae, face, and back for 2 months. Treatment with topical steroids was ineffective, and edematous erythema and tense bullae developed on her lower limbs. Direct immunofluorescence detected linear deposition of IgG and C3 along the basement membrane zone. Anti-BP180 and anti-Dsg 1 antibodies were also detected by enzyme-linked immunosorbent assay.",
author = "Miki Ichikawa and Maya Tanaka and Kazunori Urabe and Masutaka Furue",
year = "2013",
month = "1",
day = "1",
doi = "10.2336/nishinihonhifu.75.415",
language = "English",
volume = "75",
pages = "415--418",
journal = "Nishinihon Journal of Dermatology",
issn = "0386-9784",
publisher = "Kyushu University, Faculty of Science",
number = "5",

}

TY - JOUR

T1 - Autoimmune blistering disease with concurrent IgG antibodies to desmoglein 1 and BP180

T2 - Two cases

AU - Ichikawa, Miki

AU - Tanaka, Maya

AU - Urabe, Kazunori

AU - Furue, Masutaka

PY - 2013/1/1

Y1 - 2013/1/1

N2 - We report two cases with concurrent detection of antibodies to Desmoglein 1 and BP180. In Case 1, a 78-year-old man was diagnosed with bullous pemphigoid and had been treated with oral prednisolone for 2 years. He developed crusted erythema on his face and trunk despite the well-controlled state of his bullous pemphigoid. Direct immunofluorescence detected intracellular deposition of IgG in the epidermis, and anti-BP180 and anti-Dsg 1 antibodies were detected byenzy melinked immunosorbent assay. In Case 2, a 91-year-old woman had had pruritic erythema with crusting on her thighs, axillae, face, and back for 2 months. Treatment with topical steroids was ineffective, and edematous erythema and tense bullae developed on her lower limbs. Direct immunofluorescence detected linear deposition of IgG and C3 along the basement membrane zone. Anti-BP180 and anti-Dsg 1 antibodies were also detected by enzyme-linked immunosorbent assay.

AB - We report two cases with concurrent detection of antibodies to Desmoglein 1 and BP180. In Case 1, a 78-year-old man was diagnosed with bullous pemphigoid and had been treated with oral prednisolone for 2 years. He developed crusted erythema on his face and trunk despite the well-controlled state of his bullous pemphigoid. Direct immunofluorescence detected intracellular deposition of IgG in the epidermis, and anti-BP180 and anti-Dsg 1 antibodies were detected byenzy melinked immunosorbent assay. In Case 2, a 91-year-old woman had had pruritic erythema with crusting on her thighs, axillae, face, and back for 2 months. Treatment with topical steroids was ineffective, and edematous erythema and tense bullae developed on her lower limbs. Direct immunofluorescence detected linear deposition of IgG and C3 along the basement membrane zone. Anti-BP180 and anti-Dsg 1 antibodies were also detected by enzyme-linked immunosorbent assay.

UR - http://www.scopus.com/inward/record.url?scp=84895812095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895812095&partnerID=8YFLogxK

U2 - 10.2336/nishinihonhifu.75.415

DO - 10.2336/nishinihonhifu.75.415

M3 - Article

AN - SCOPUS:84895812095

VL - 75

SP - 415

EP - 418

JO - Nishinihon Journal of Dermatology

JF - Nishinihon Journal of Dermatology

SN - 0386-9784

IS - 5

ER -