TY - JOUR
T1 - Autoimmune Hepatitis in an Immunosuppression-Free Patient Who Underwent Living Donor Liver Transplantation From an Identical Twin
T2 - A Case Report
AU - Toshida, Katsuya
AU - Toshima, Takeo
AU - Harada, Noboru
AU - Nakayama, Yuki
AU - Tomiyama, Takahiro
AU - Morinaga, Akinari
AU - Kosai-Fujimoto, Yukiko
AU - Tomino, Takahiro
AU - Kurihara, Takeshi
AU - Nagao, Yoshihiro
AU - Morita, Kazutoyo
AU - Itoh, Shinji
AU - Yoshizumi, Tomoharu
N1 - Funding Information:
The authors acknowledge Jodi Smith, PhD ELS, from Edanz for editing a draft of this manuscript. This study was supported by the following 3 grants: the Program for Basic and Clinical Research on Hepatitis, from the Japan Agency for Medical Research and Development, AMED (no. 20fk0210035s0503, 20fk0310106h0204, and 19fm0208009h0003); JSPS KAKENHI, a Grant-in-Aid from the Ministry of Health, Labour and Welfare, Japan (no. JP-18K08542); and Taiju Life Social Welfare Foundation 2020. The funding sources had no role in the collection, analysis, or interpretation of the data, or in the decision to submit the article for publication.
Publisher Copyright:
© 2022
PY - 2022
Y1 - 2022
N2 - Although there have been a few liver transplantations (LTs) between identical twins, to our knowledge hepatic damage after LT in an immunosuppressant-free patient has not been reported. Autoimmune liver disease recurrence after LT is also a postoperative problem. In this follow-up to our previous report, we present the case of a 57-year-old man with acute liver failure who underwent living donor liver transplantation (LDLT) from an identical twin. Six months after LDLT, the patient was free from immunosuppressive medication and showed good liver function. However, 1 year after LDLT, he developed liver damage and was diagnosed with autoimmune hepatitis by liver biopsy. His liver function was improved with steroid pulse therapy and the resumption of immunosuppressive medications. Even after LDLT from an identical twin, careful management is required for patients to remain free of immunosuppressive medications, considering the background liver disease.
AB - Although there have been a few liver transplantations (LTs) between identical twins, to our knowledge hepatic damage after LT in an immunosuppressant-free patient has not been reported. Autoimmune liver disease recurrence after LT is also a postoperative problem. In this follow-up to our previous report, we present the case of a 57-year-old man with acute liver failure who underwent living donor liver transplantation (LDLT) from an identical twin. Six months after LDLT, the patient was free from immunosuppressive medication and showed good liver function. However, 1 year after LDLT, he developed liver damage and was diagnosed with autoimmune hepatitis by liver biopsy. His liver function was improved with steroid pulse therapy and the resumption of immunosuppressive medications. Even after LDLT from an identical twin, careful management is required for patients to remain free of immunosuppressive medications, considering the background liver disease.
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U2 - 10.1016/j.transproceed.2022.09.022
DO - 10.1016/j.transproceed.2022.09.022
M3 - Article
C2 - 36396466
AN - SCOPUS:85142290337
SN - 0041-1345
JO - Transplantation Proceedings
JF - Transplantation Proceedings
ER -
