Autoimmune regulator (AIRE) gene is expressed in human activated CD4 + T-cells and regulated by mitogen-activated protein kinase pathway

Seiho Nagafuchi, Hitoshi Katsuta, Rimiko Koyanagi-Katsuta, Satoshi Yamasaki, Yasushi Inoue, Kazuya Shimoda, Yukari Ikeda, Mieko Shindo, Eiko Yoshida, Tomohito Matsuo, Yuju Ohno, Kazuhiko Kogawa, Keizo Anzai, Hironori Kurisaki, Jun Kudoh, Mine Harada, Nobuyoshi Shimizu

研究成果: Contribution to journalArticle

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The autoimmune regulator (AIRE) gene is a gene responsible for autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Here we show that AIRE is expressed in human peripheral CD4-positive T-cells, and most highly in antigen- and interleukin 2-stimulated T (IL-2T) cells. Mitogen-activated protein kinases (MAPKs), including MAPK kinase (MEK) 1/2 and p38 MAPK, were phosphorylated in IL-2T cells and the expression of the AIRE gene was inhibited by a specific p38 MAPK inhibitor (SB203580), thereby indicating that AIRE gene expression is controlled by the MAPK pathway in IL-2T cells. These data suggested the possible significance of the AIRE gene in the peripheral immune system.

元の言語英語
ページ(範囲)979-987
ページ数9
ジャーナルMICROBIOLOGY and IMMUNOLOGY
50
発行部数12
DOI
出版物ステータス出版済み - 2006

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Virology

フィンガープリント Autoimmune regulator (AIRE) gene is expressed in human activated CD4 <sup>+</sup> T-cells and regulated by mitogen-activated protein kinase pathway' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Nagafuchi, S., Katsuta, H., Koyanagi-Katsuta, R., Yamasaki, S., Inoue, Y., Shimoda, K., Ikeda, Y., Shindo, M., Yoshida, E., Matsuo, T., Ohno, Y., Kogawa, K., Anzai, K., Kurisaki, H., Kudoh, J., Harada, M., & Shimizu, N. (2006). Autoimmune regulator (AIRE) gene is expressed in human activated CD4 + T-cells and regulated by mitogen-activated protein kinase pathway. MICROBIOLOGY and IMMUNOLOGY, 50(12), 979-987. https://doi.org/10.1111/j.1348-0421.2006.tb03876.x