Autophagy in the fission yeast Schizosaccharomyces pombe

Hiroyuki Mukaiyama, Mai Nakase, Taro Nakamura, Yoshimi Kakinuma, Kaoru Takegawa

研究成果: Contribution to journalReview article査読

27 被引用数 (Scopus)

抄録

Autophagy is a non-selective degradation process in eukaryotic cells. The genome sequence of the fission yeast Schizosaccharomyces pombe has revealed that many of the genes required for autophagy are common between the fission yeast and budding yeast, suggesting that the basic machinery of autophagy is conserved between these species. Autophagy in fission yeast is specifically induced by nitrogen starvation based on monitoring a GFP-Atg8p marker. Upon nitrogen starvation, fission yeast cells exit the vegetative cell cycle and initiate sexual differentiation to produce spores. Most of the nitrogen used for de novo protein synthesis during sporulation derives from the autophagic protein degradation system. This review focuses on the recent advances in the role of autophagy in fission yeast.

本文言語英語
ページ(範囲)1327-1334
ページ数8
ジャーナルFEBS Letters
584
7
DOI
出版ステータス出版済み - 4 2010

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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