Availability of a novel criterion for peritoneal diffusive selectivity on peritoneal dialysis

Hiroyuki Hamada, A. A. Mamun, T. Karino, S. Namoto, A. C. Yamashita, M. Ishizaki, Masahiro Okamoto

研究成果: ジャーナルへの寄稿Conference article

1 引用 (Scopus)

抄録

In the peritoneal dialysis, it is well-known that the peritoneal permeability increases gradually over the duration of treatment. The enhancement of the peritoneal permeability causes an under-dialysis and ultrafiltration failure, which is one of the grave factors which disrupt the homeostasis of body fluid. Hence, the monitoring of the peritoneal permeability is very important in order to give each patient some better prescriptions. In this study, we designed a novel criterion which can evaluate quantitatively the peritoneal permeability by applying a kinetic model for the peritoneal dialysis. Moreover clinical implementations of the novel criterion were validated with using the clinical data. By employing PD NAVI (JMS Co.,Ltd., Hiroshima, Japan), 50 well-being peritoneal dialysis patients performed the peritoneal function test including the peritoneal equilibration test (PET), which measured both urea and creatinine concentrations in the dialysate and drainage volumes. The overall mass transfer area coefficient for urea (MTACu) and that for creatinine (MTACc) were determined from a peritoneal mass transfer model and the clinical data for each patient. An average of MTACu/c which is the ratio of MTACu to MTACc was 1.78 and a standard deviation of that was 0.32. MTACu/c correlated with the drainage volume of PET (r 2 >0.66). Moreover a decrease of MTACu/c showed the enhancement of the peritoneal permeability (p<0.0001). Furthermore, since MTACu/c implies a peritoneal diffusive selectivity, MTACu/c also correlated with dialysis outcomes such as Kt/V for urea and weekly creatinine clearance normalized to 1.73m 2 . Then, we could derive some recommendations for MTACu/c by applying the recommendations for the dialysis outcomes such as NKF-DOQI guideline. Thus, MTACu/c can evaluate not only the peritoneal permeability, but also the dialysis outcome. We proposed that MTACu/c is available as the criterion which manages the peritoneal permeability and the therapeutic efficiency of the peritoneal dialysis.

元の言語英語
ページ(範囲)3201-3204
ページ数4
ジャーナルIFMBE Proceedings
14
発行部数1
出版物ステータス出版済み - 1 1 2007
イベント10th World Congress on Medical Physics and Biomedical Engineering, WC 2006 - Seoul, 大韓民国
継続期間: 8 27 20069 1 2006

Fingerprint

Dialysis
Urea
Availability
Mass transfer
Creatinine
Drainage
Body fluids
Dialysis Solutions
Ultrafiltration

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

これを引用

Hamada, H., Mamun, A. A., Karino, T., Namoto, S., Yamashita, A. C., Ishizaki, M., & Okamoto, M. (2007). Availability of a novel criterion for peritoneal diffusive selectivity on peritoneal dialysis. IFMBE Proceedings, 14(1), 3201-3204.

Availability of a novel criterion for peritoneal diffusive selectivity on peritoneal dialysis. / Hamada, Hiroyuki; Mamun, A. A.; Karino, T.; Namoto, S.; Yamashita, A. C.; Ishizaki, M.; Okamoto, Masahiro.

:: IFMBE Proceedings, 巻 14, 番号 1, 01.01.2007, p. 3201-3204.

研究成果: ジャーナルへの寄稿Conference article

Hamada, H, Mamun, AA, Karino, T, Namoto, S, Yamashita, AC, Ishizaki, M & Okamoto, M 2007, 'Availability of a novel criterion for peritoneal diffusive selectivity on peritoneal dialysis', IFMBE Proceedings, 巻. 14, 番号 1, pp. 3201-3204.
Hamada H, Mamun AA, Karino T, Namoto S, Yamashita AC, Ishizaki M その他. Availability of a novel criterion for peritoneal diffusive selectivity on peritoneal dialysis. IFMBE Proceedings. 2007 1 1;14(1):3201-3204.
Hamada, Hiroyuki ; Mamun, A. A. ; Karino, T. ; Namoto, S. ; Yamashita, A. C. ; Ishizaki, M. ; Okamoto, Masahiro. / Availability of a novel criterion for peritoneal diffusive selectivity on peritoneal dialysis. :: IFMBE Proceedings. 2007 ; 巻 14, 番号 1. pp. 3201-3204.
@article{aa9b6f5ca20743d1bec7c22fca2325e1,
title = "Availability of a novel criterion for peritoneal diffusive selectivity on peritoneal dialysis",
abstract = "In the peritoneal dialysis, it is well-known that the peritoneal permeability increases gradually over the duration of treatment. The enhancement of the peritoneal permeability causes an under-dialysis and ultrafiltration failure, which is one of the grave factors which disrupt the homeostasis of body fluid. Hence, the monitoring of the peritoneal permeability is very important in order to give each patient some better prescriptions. In this study, we designed a novel criterion which can evaluate quantitatively the peritoneal permeability by applying a kinetic model for the peritoneal dialysis. Moreover clinical implementations of the novel criterion were validated with using the clinical data. By employing PD NAVI (JMS Co.,Ltd., Hiroshima, Japan), 50 well-being peritoneal dialysis patients performed the peritoneal function test including the peritoneal equilibration test (PET), which measured both urea and creatinine concentrations in the dialysate and drainage volumes. The overall mass transfer area coefficient for urea (MTACu) and that for creatinine (MTACc) were determined from a peritoneal mass transfer model and the clinical data for each patient. An average of MTACu/c which is the ratio of MTACu to MTACc was 1.78 and a standard deviation of that was 0.32. MTACu/c correlated with the drainage volume of PET (r 2 >0.66). Moreover a decrease of MTACu/c showed the enhancement of the peritoneal permeability (p<0.0001). Furthermore, since MTACu/c implies a peritoneal diffusive selectivity, MTACu/c also correlated with dialysis outcomes such as Kt/V for urea and weekly creatinine clearance normalized to 1.73m 2 . Then, we could derive some recommendations for MTACu/c by applying the recommendations for the dialysis outcomes such as NKF-DOQI guideline. Thus, MTACu/c can evaluate not only the peritoneal permeability, but also the dialysis outcome. We proposed that MTACu/c is available as the criterion which manages the peritoneal permeability and the therapeutic efficiency of the peritoneal dialysis.",
author = "Hiroyuki Hamada and Mamun, {A. A.} and T. Karino and S. Namoto and Yamashita, {A. C.} and M. Ishizaki and Masahiro Okamoto",
year = "2007",
month = "1",
day = "1",
language = "English",
volume = "14",
pages = "3201--3204",
journal = "IFMBE Proceedings",
issn = "1680-0737",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Availability of a novel criterion for peritoneal diffusive selectivity on peritoneal dialysis

AU - Hamada, Hiroyuki

AU - Mamun, A. A.

AU - Karino, T.

AU - Namoto, S.

AU - Yamashita, A. C.

AU - Ishizaki, M.

AU - Okamoto, Masahiro

PY - 2007/1/1

Y1 - 2007/1/1

N2 - In the peritoneal dialysis, it is well-known that the peritoneal permeability increases gradually over the duration of treatment. The enhancement of the peritoneal permeability causes an under-dialysis and ultrafiltration failure, which is one of the grave factors which disrupt the homeostasis of body fluid. Hence, the monitoring of the peritoneal permeability is very important in order to give each patient some better prescriptions. In this study, we designed a novel criterion which can evaluate quantitatively the peritoneal permeability by applying a kinetic model for the peritoneal dialysis. Moreover clinical implementations of the novel criterion were validated with using the clinical data. By employing PD NAVI (JMS Co.,Ltd., Hiroshima, Japan), 50 well-being peritoneal dialysis patients performed the peritoneal function test including the peritoneal equilibration test (PET), which measured both urea and creatinine concentrations in the dialysate and drainage volumes. The overall mass transfer area coefficient for urea (MTACu) and that for creatinine (MTACc) were determined from a peritoneal mass transfer model and the clinical data for each patient. An average of MTACu/c which is the ratio of MTACu to MTACc was 1.78 and a standard deviation of that was 0.32. MTACu/c correlated with the drainage volume of PET (r 2 >0.66). Moreover a decrease of MTACu/c showed the enhancement of the peritoneal permeability (p<0.0001). Furthermore, since MTACu/c implies a peritoneal diffusive selectivity, MTACu/c also correlated with dialysis outcomes such as Kt/V for urea and weekly creatinine clearance normalized to 1.73m 2 . Then, we could derive some recommendations for MTACu/c by applying the recommendations for the dialysis outcomes such as NKF-DOQI guideline. Thus, MTACu/c can evaluate not only the peritoneal permeability, but also the dialysis outcome. We proposed that MTACu/c is available as the criterion which manages the peritoneal permeability and the therapeutic efficiency of the peritoneal dialysis.

AB - In the peritoneal dialysis, it is well-known that the peritoneal permeability increases gradually over the duration of treatment. The enhancement of the peritoneal permeability causes an under-dialysis and ultrafiltration failure, which is one of the grave factors which disrupt the homeostasis of body fluid. Hence, the monitoring of the peritoneal permeability is very important in order to give each patient some better prescriptions. In this study, we designed a novel criterion which can evaluate quantitatively the peritoneal permeability by applying a kinetic model for the peritoneal dialysis. Moreover clinical implementations of the novel criterion were validated with using the clinical data. By employing PD NAVI (JMS Co.,Ltd., Hiroshima, Japan), 50 well-being peritoneal dialysis patients performed the peritoneal function test including the peritoneal equilibration test (PET), which measured both urea and creatinine concentrations in the dialysate and drainage volumes. The overall mass transfer area coefficient for urea (MTACu) and that for creatinine (MTACc) were determined from a peritoneal mass transfer model and the clinical data for each patient. An average of MTACu/c which is the ratio of MTACu to MTACc was 1.78 and a standard deviation of that was 0.32. MTACu/c correlated with the drainage volume of PET (r 2 >0.66). Moreover a decrease of MTACu/c showed the enhancement of the peritoneal permeability (p<0.0001). Furthermore, since MTACu/c implies a peritoneal diffusive selectivity, MTACu/c also correlated with dialysis outcomes such as Kt/V for urea and weekly creatinine clearance normalized to 1.73m 2 . Then, we could derive some recommendations for MTACu/c by applying the recommendations for the dialysis outcomes such as NKF-DOQI guideline. Thus, MTACu/c can evaluate not only the peritoneal permeability, but also the dialysis outcome. We proposed that MTACu/c is available as the criterion which manages the peritoneal permeability and the therapeutic efficiency of the peritoneal dialysis.

UR - http://www.scopus.com/inward/record.url?scp=84958248651&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958248651&partnerID=8YFLogxK

M3 - Conference article

VL - 14

SP - 3201

EP - 3204

JO - IFMBE Proceedings

JF - IFMBE Proceedings

SN - 1680-0737

IS - 1

ER -