Avt5p is required for vacuolar uptake of amino acids in the fission yeast Schizosaccharomyces pombe

Soracom Chardwiriyapreecha, Hiroyuki Mukaiyama, Takayuki Sekito, Tomoko Iwaki, Kaoru Takegawa, Yoshimi Kakinuma

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

We identified SPBC1685.07c of Schizosaccharomyces pombe as a novel vacuolar protein, Avt5p, with similarity to vacuolar amino acid transporters Avt5p from Saccharomyces cerevisiae. Avt5p localizes to the vacuolar membrane and upon disruption of avt5, uptake of histidine, glutamate, tyrosine, arginine, lysine or serine was impaired. During nitrogen starvation, the transient increase of vacuolar lysine transport observed for wild-type cells still occurred in the mutant cells, however, uptake of glutamate did not significantly increase in response to nitrogen starvation. Our results show that under diverse growth conditions Avt5p is involved in vacuolar transport of a selective set of amino acids.

本文言語英語
ページ(範囲)2339-2345
ページ数7
ジャーナルFEBS Letters
584
11
DOI
出版ステータス出版済み - 6 1 2010

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

フィンガープリント 「Avt5p is required for vacuolar uptake of amino acids in the fission yeast Schizosaccharomyces pombe」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル