(-)-Axinyssene: A novel cytotoxic diterpene from a Japanese marine sponge Axinyssa sp

Kota Kodama; Ryuichi Higuchi; Tomofumi Miyamoto; Rob W.M. Van Soest

doi:10.1021/ol027202f

(-)-Axinyssene: A novel cytotoxic diterpene from a Japanese marine sponge Axinyssa sp

Kota Kodama, Ryuichi Higuchi, Tomofumi Miyamoto, Rob W.M. Van Soest

生命薬学

研究成果: Contribution to journal › Article › 査読

18 被引用数 (Scopus)

抄録

(Matrix presented) A novel diterpene, (-)-axinyssene, was isolated from the Japanese marine sponge Axinyssa sp. The structure of (-)-axinyssene was determined on the basis of spectroscopic and synthetic evidence to be 1-methyl-4-[(4E)-5′9′-dimethyl-1′-methylene-4′, 8′-decadienyl]-(4S)-cyclohexene. (-)- and (+)-axinyssene showed mild cytotoxicity against acute promyelocytic leukemia, HL-60 cells.

本文言語	英語
ページ（範囲）	169-171
ページ数	3
ジャーナル	Organic Letters
巻	5
号	2
DOI	https://doi.org/10.1021/ol027202f
出版ステータス	出版済み - 1 23 2003

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

文献へのアクセス

10.1021/ol027202f

他のファイルとリンク

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引用スタイル

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author = "Kota Kodama and Ryuichi Higuchi and Tomofumi Miyamoto and {Van Soest}, {Rob W.M.}",

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AU - Higuchi, Ryuichi

AU - Miyamoto, Tomofumi

AU - Van Soest, Rob W.M.

PY - 2003/1/23

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