(-)-Axinyssene: A novel cytotoxic diterpene from a Japanese marine sponge Axinyssa sp

Kota Kodama; Ryuichi Higuchi; Tomofumi Miyamoto; Rob W.M. Van Soest

doi:10.1021/ol027202f

(-)-Axinyssene: A novel cytotoxic diterpene from a Japanese marine sponge Axinyssa sp

Kota Kodama, Ryuichi Higuchi, Tomofumi Miyamoto, Rob W.M. Van Soest

生命薬学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

19 被引用数 (Scopus)

抄録

(Matrix presented) A novel diterpene, (-)-axinyssene, was isolated from the Japanese marine sponge Axinyssa sp. The structure of (-)-axinyssene was determined on the basis of spectroscopic and synthetic evidence to be 1-methyl-4-[(4E)-5′9′-dimethyl-1′-methylene-4′, 8′-decadienyl]-(4S)-cyclohexene. (-)- and (+)-axinyssene showed mild cytotoxicity against acute promyelocytic leukemia, HL-60 cells.

本文言語	英語
ページ（範囲）	169-171
ページ数	3
ジャーナル	Organic Letters
巻	5
号	2
DOI	https://doi.org/10.1021/ol027202f
出版ステータス	出版済み - 1月 23 2003

!!!All Science Journal Classification (ASJC) codes

生化学
物理化学および理論化学
有機化学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1021/ol027202f

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title = "(-)-Axinyssene: A novel cytotoxic diterpene from a Japanese marine sponge Axinyssa sp",

abstract = "(Matrix presented) A novel diterpene, (-)-axinyssene, was isolated from the Japanese marine sponge Axinyssa sp. The structure of (-)-axinyssene was determined on the basis of spectroscopic and synthetic evidence to be 1-methyl-4-[(4E)-5′9′-dimethyl-1′-methylene-4′, 8′-decadienyl]-(4S)-cyclohexene. (-)- and (+)-axinyssene showed mild cytotoxicity against acute promyelocytic leukemia, HL-60 cells.",

author = "Kota Kodama and Ryuichi Higuchi and Tomofumi Miyamoto and {Van Soest}, {Rob W.M.}",

year = "2003",

month = jan,

day = "23",

doi = "10.1021/ol027202f",

language = "English",

volume = "5",

pages = "169--171",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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TY - JOUR

T1 - (-)-Axinyssene

T2 - A novel cytotoxic diterpene from a Japanese marine sponge Axinyssa sp

AU - Kodama, Kota

AU - Higuchi, Ryuichi

AU - Miyamoto, Tomofumi

AU - Van Soest, Rob W.M.

PY - 2003/1/23

Y1 - 2003/1/23

N2 - (Matrix presented) A novel diterpene, (-)-axinyssene, was isolated from the Japanese marine sponge Axinyssa sp. The structure of (-)-axinyssene was determined on the basis of spectroscopic and synthetic evidence to be 1-methyl-4-[(4E)-5′9′-dimethyl-1′-methylene-4′, 8′-decadienyl]-(4S)-cyclohexene. (-)- and (+)-axinyssene showed mild cytotoxicity against acute promyelocytic leukemia, HL-60 cells.

AB - (Matrix presented) A novel diterpene, (-)-axinyssene, was isolated from the Japanese marine sponge Axinyssa sp. The structure of (-)-axinyssene was determined on the basis of spectroscopic and synthetic evidence to be 1-methyl-4-[(4E)-5′9′-dimethyl-1′-methylene-4′, 8′-decadienyl]-(4S)-cyclohexene. (-)- and (+)-axinyssene showed mild cytotoxicity against acute promyelocytic leukemia, HL-60 cells.

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U2 - 10.1021/ol027202f

DO - 10.1021/ol027202f

M3 - Article

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VL - 5

SP - 169

EP - 171

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 2

ER -

(-)-Axinyssene: A novel cytotoxic diterpene from a Japanese marine sponge Axinyssa sp

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!!!All Science Journal Classification (ASJC) codes

UN SDG

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