Axonal transport is inhibited by a protein kinase C inhibitor in cultured isolated mouse dorsal root ganglion cells

Hiromi Hiruma, Hiroshi Maruyama, Takashi Katakura, Zyun'ici B. Simada, Sanae Nishida, Sumio Hoka, Toshifumi Takenaka, Tadashi Kawakami

研究成果: Contribution to journalArticle査読

13 被引用数 (Scopus)

抄録

We investigated roles of protein kinase C (PKC) and Ca2+/calmodulin- dependent protein II (CAM II) kinase activities in the maintenance of axonal transport in cultured isolated mouse dorsal root ganglion (DRG) cells. Video- enhanced microscopic recordings revealed that the PKC inhibitor chelerythrine (1 μM) reduced anterograde and retrograde axonal transport, while the CAM II kinase inhibitor KN-62 (10 μM) had no effect. Morphological observation showed that neurite growth was prevented by the presence of chelerythrine (1 μM). From these results, we conclude that PKC activity is required to maintain axonal transport and thereby neurite growth.

本文言語英語
ページ(範囲)135-138
ページ数4
ジャーナルBrain Research
826
1
DOI
出版ステータス出版済み - 4 24 1999

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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