B lymphopoiesis in the thymus

Koichi Akashi, Lauren I. Richie, Toshihiro Miyamoto, William H. Carr, Irving L. Weissman

研究成果: ジャーナルへの寄稿学術誌査読

108 被引用数 (Scopus)

抄録

The thymus has been regarded as the major site of T cell differentiation. We find that in addition to αβ and γδ T cells, a significant number (~3 x 104 per day) of B220+IgM+ mature B cells are exported from the thymus of C57BL/6 mice. Of these emigrating B cells, we estimate that at least ~2 x 104 per day are cells which developed intrathymically, whereas a maximum of ~0.8 x 104 per day are cells which circulated through the thymus from the periphery. The thymus possesses a significant number of pro-B and pre-B cells that express CD19, VpreB, λ5, and pax-5. These B cell progenitors were found in the thymic cortex, whereas increasingly mature B cells were found in the corticomedullar and medullary regions. Other lymphoid cells, including NK cells and lymphoid dendritic cells, are not exported from the thymus at detectable levels. Thus, the thymus contributes to the formation of peripheral pools of B cells as well as of αβ and γδ T cells.

本文言語英語
ページ(範囲)5221-5226
ページ数6
ジャーナルJournal of Immunology
164
10
DOI
出版ステータス出版済み - 5月 15 2000
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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