Bacterial diversity in saliva and oral health-related conditions: The Hisayama Study

Toru Takeshita, Shinya Kageyama, Michiko Furuta, Hidenori Tsuboi, Kenji Takeuchi, Yukie Shibata, Yoshihiro Shimazaki, Sumio Akifusa, Toshiharu Ninomiya, Yutaka Kiyohara, Yoshihisa Yamashita

研究成果: ジャーナルへの寄稿記事

51 引用 (Scopus)

抄録

This population-based study determined the salivary microbiota composition of 2,343 adult residents of Hisayama town, Japan, using 16S rRNA gene next-generation high-throughput sequencing. Of 550 identified species-level operational taxonomic units (OTUs), 72 were common, in ≥75% of all individuals, as well as in ≥75% of the individuals in the lowest quintile of phylogenetic diversity (PD). These "core" OTUs constituted 90.9 ± 6.1% of each microbiome. The relative abundance profiles of 22 of the core OTUs with mean relative abundances ≥1% were stratified into community type I and community type II by partitioning around medoids clustering. Multiple regression analysis revealed that a lower PD was associated with better conditions for oral health, including a lower plaque index, absence of decayed teeth, less gingival bleeding, shallower periodontal pockets and not smoking, and was also associated with tooth loss. By contrast, multiple Poisson regression analysis demonstrated that community type II, as characterized by a higher ratio of the nine dominant core OTUs, including Neisseria flavescens, was implicated in younger age, lower body mass index, fewer teeth with caries experience, and not smoking. Our large-scale data analyses reveal variation in the salivary microbiome among Japanese adults and oral health-related conditions associated with the salivary microbiome.

元の言語英語
記事番号22164
ジャーナルScientific reports
6
DOI
出版物ステータス出版済み - 2 24 2016

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Microbiota
Oral Health
Saliva
Tooth
Smoking
Regression Analysis
Periodontal Pocket
Neisseria
Tooth Loss
rRNA Genes
Cluster Analysis
Japan
Body Mass Index
Hemorrhage
Population

All Science Journal Classification (ASJC) codes

  • General

これを引用

Bacterial diversity in saliva and oral health-related conditions : The Hisayama Study. / Takeshita, Toru; Kageyama, Shinya; Furuta, Michiko; Tsuboi, Hidenori; Takeuchi, Kenji; Shibata, Yukie; Shimazaki, Yoshihiro; Akifusa, Sumio; Ninomiya, Toshiharu; Kiyohara, Yutaka; Yamashita, Yoshihisa.

:: Scientific reports, 巻 6, 22164, 24.02.2016.

研究成果: ジャーナルへの寄稿記事

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AU - Shimazaki, Yoshihiro

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