Bacterial sepsis after living donor liver transplantation: The impact of early enteral nutrition

Toru Ikegami, Ken Shirabe, Shohei Yoshiya, Tomoharu Yoshizumi, Mizuki Ninomiya, Hideaki Uchiyama, Yuji Soejima, Yoshihiko Maehara

研究成果: Contribution to journalArticle査読

38 被引用数 (Scopus)

抄録

Background: Bacterial sepsis is a significant problem that must be addressed after living donor liver transplantation (LDLT). Study Design: A retrospective analysis of 346 adult-to-adult LDLT patients was performed. Results: Forty-six patients (13.3%) experienced bacterial sepsis, with primary and secondary origins in 23.9% and 76.1%, respectively. Gram-negative bacteria accounted for 71.7% of the bacteria isolated. The 2-year cumulative graft survival rate in patients with bacterial sepsis was 45.7%. Patients with bacterial sepsis secondary to pneumonia (n = 12) had poorer 2-year graft survival rates (16.7%) than did those with primary or other types of secondary sepsis (p = 0.004). Multivariate analysis showed that intraoperative massive blood loss >10L (p < 0.001) and no enteral feeding started within 48 hours after transplantation (p = 0.005) were significant risk factors for bacterial sepsis. Among patients who received enteral nutrition, the incidences of bacterial sepsis in patients who received enteral nutrition within 48 hours (n = 135) or later than 48 hours (n = 57) were 5.9% and 21.0%, respectively (p = 0.002). The incidence of early graft loss was 8-fold higher in recipients with massive intraoperative blood loss without early enteral nutrition (p < 0.001). Conclusions: Early enteral nutrition was associated with significantly reduced risk of developing bacterial sepsis after LDLT.

本文言語英語
ページ(範囲)288-295
ページ数8
ジャーナルJournal of the American College of Surgeons
214
3
DOI
出版ステータス出版済み - 3 2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • 外科

フィンガープリント

「Bacterial sepsis after living donor liver transplantation: The impact of early enteral nutrition」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル