TY - JOUR
T1 - Baroreceptor reflex in elderly essential hypertensives
T2 - Effect of chronic inhibition of angiotensin converting enzyme
AU - Muratani, H.
AU - Kimura, Y.
AU - Matsumura, K.
AU - Noda, Y.
AU - Eto, T.
AU - Fukiyama, K.
N1 - Funding Information:
ACKNOWLEDGMENT We thank Professor Iimura and Dr. Shimamoto of Sapporo Medical College for their kind gift of Ang I1 antibody. We thank Miss Chiemi Tanahara for her technical assistance, and Dr. Marc Schiavone of the Cleveland Clinic Foundation for editorial assistance. This study was supported by a grant from the Ministry of Health and Welfare (62A-6).
PY - 1990
Y1 - 1990
N2 - Baroreflex function and plasma angiotensin II (Ang II) were examined in five elderly and five young or middle-aged essential hypertensive patients before and after enalapril treatment. Baroreflex sensitivity (BS) during blood pressure (BP) elevation by phenylephrine (PE) but not during BP reduction by sodium nitroprusside (SNP) was significantly attenuated in the elderly compared with the younger group, while plasma Ang II concentration was not different between the two groups. Enalapril treatment reduced BP without significant changes in heart rate and plasma norepinephrine in both groups, suggesting a leftward shift of barofunction curve. It also increased the BS in some cases in each group. However, plasma Ang II was not significantly reduced during enalapril treatment. The changes in BS did not correlate with changes in plasma Ang II. These results suggest that BS may be attenuated with increasing age independent of plasma Ang II and that ACE inhibitor influences the set point of the barofunction curve and BS by different mechanisms.
AB - Baroreflex function and plasma angiotensin II (Ang II) were examined in five elderly and five young or middle-aged essential hypertensive patients before and after enalapril treatment. Baroreflex sensitivity (BS) during blood pressure (BP) elevation by phenylephrine (PE) but not during BP reduction by sodium nitroprusside (SNP) was significantly attenuated in the elderly compared with the younger group, while plasma Ang II concentration was not different between the two groups. Enalapril treatment reduced BP without significant changes in heart rate and plasma norepinephrine in both groups, suggesting a leftward shift of barofunction curve. It also increased the BS in some cases in each group. However, plasma Ang II was not significantly reduced during enalapril treatment. The changes in BS did not correlate with changes in plasma Ang II. These results suggest that BS may be attenuated with increasing age independent of plasma Ang II and that ACE inhibitor influences the set point of the barofunction curve and BS by different mechanisms.
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U2 - 10.3109/10641969009074722
DO - 10.3109/10641969009074722
M3 - Article
C2 - 2407393
AN - SCOPUS:0025100827
SN - 1064-1963
VL - A12
SP - 97
EP - 110
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
IS - 1
ER -