Basal release of endothelium-derived nitric oxide at site of spasm in patients with variant angina

Kensuke Egashira, Yousuke Katsuda, Masahiro Mohri, Takeshi Kuga, Tatuya Tagawa, Hiroaki Shimokawa, Akira Takeshita

研究成果: Contribution to journalArticle査読

49 被引用数 (Scopus)

抄録

Objectives. The aim of this study was to investigate the basal release of nitric oxide at spastic sites in patients with variant angina. Background. We previously reported that endothelium-dependent dilator responses to acetylcholine, substance P and bradykinin are preserved at the site of coronary artery spasm. However, it is not known whether the basal release of endothelium-derived nitric oxide is altered at the spastic site. Methods. The effects of intracoronary N(G)-monomethyl-L-arginine (L-NMMA, an inhibitor of nitric oxide synthesis) at cumulative doses of 50, 100 and 200 μmol on basal coronary artery tone were investigated in eight patients with variant angina and normal coronary angiograms and in eight control subjects. The lumen diameters of large epicardial coronary arteries were assessed by quantitative coronary arteriography. Results. Coronary spasm was provoked by the intracoronary administration of acetylcholine in all patients with variant angina. L-NMMA did not alter the arterial pressure and heart rate but significantly decreased the coronary artery diameter at spastic and nonspastic sites. Constrictive responses to L-NMMA were significantly greater (p < 0.01) at the spastic site (constriction by 200 μmol, 22 ± 7%, mean ± SD) than at the nonspastic site (10 ± 7%). Constrictive responses to L-NMMA at the nonspastic site in patients with variant angina were comparable to those in the control subjects. Conclusions. These findings support the hypothesis that the basal release of nitric oxide may not be decreased at the spastic site in patients with variant angina.

本文言語英語
ページ(範囲)1444-1449
ページ数6
ジャーナルJournal of the American College of Cardiology
27
6
DOI
出版ステータス出版済み - 5 1996
外部発表はい

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

フィンガープリント

「Basal release of endothelium-derived nitric oxide at site of spasm in patients with variant angina」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル