Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation

Hiromitsu Araki, Fumihito Miura, Akira Watanabe, Chikako Morinaga, Fumiyo Kitaoka, Yuko Kitano, Noriko Sakai, Yumiko Shibata, Motoki Terada, So Goto, Shinya Yamanaka, Masayo Takahashi, Takashi Ito

研究成果: ジャーナルへの寄稿記事

抄録

In this article, Ito and colleagues delineated the base-resolution methylome of iPSC-derived retinal pigment epithelial (RPE) cell used in the first-in-human trial of autologous transplantation. The methylome closely resembled that of native RPE cell. Intriguingly, it became even closer to its natural counterpart upon xenotransplantation to mouse, demonstrating its plasticity to respond appropriately to the in vivo environment.

元の言語英語
ページ(範囲)761-774
ページ数14
ジャーナルStem Cell Reports
13
発行部数4
DOI
出版物ステータス出版済み - 10 8 2019

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Induced Pluripotent Stem Cells
Retinal Pigments
Autologous Transplantation
Stem cells
Epithelial Cells
Heterologous Transplantation
Plasticity

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

これを引用

Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation. / Araki, Hiromitsu; Miura, Fumihito; Watanabe, Akira; Morinaga, Chikako; Kitaoka, Fumiyo; Kitano, Yuko; Sakai, Noriko; Shibata, Yumiko; Terada, Motoki; Goto, So; Yamanaka, Shinya; Takahashi, Masayo; Ito, Takashi.

:: Stem Cell Reports, 巻 13, 番号 4, 08.10.2019, p. 761-774.

研究成果: ジャーナルへの寄稿記事

Araki, Hiromitsu ; Miura, Fumihito ; Watanabe, Akira ; Morinaga, Chikako ; Kitaoka, Fumiyo ; Kitano, Yuko ; Sakai, Noriko ; Shibata, Yumiko ; Terada, Motoki ; Goto, So ; Yamanaka, Shinya ; Takahashi, Masayo ; Ito, Takashi. / Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation. :: Stem Cell Reports. 2019 ; 巻 13, 番号 4. pp. 761-774.
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AU - Watanabe, Akira

AU - Morinaga, Chikako

AU - Kitaoka, Fumiyo

AU - Kitano, Yuko

AU - Sakai, Noriko

AU - Shibata, Yumiko

AU - Terada, Motoki

AU - Goto, So

AU - Yamanaka, Shinya

AU - Takahashi, Masayo

AU - Ito, Takashi

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