Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation

Hiromitsu Araki, Fumihito Miura, Akira Watanabe, Chikako Morinaga, Fumiyo Kitaoka, Yuko Kitano, Noriko Sakai, Yumiko Shibata, Motoki Terada, So Goto, Shinya Yamanaka, Masayo Takahashi, Takashi Ito

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)

抄録

In this article, Ito and colleagues delineated the base-resolution methylome of iPSC-derived retinal pigment epithelial (RPE) cell used in the first-in-human trial of autologous transplantation. The methylome closely resembled that of native RPE cell. Intriguingly, it became even closer to its natural counterpart upon xenotransplantation to mouse, demonstrating its plasticity to respond appropriately to the in vivo environment.

本文言語英語
ページ(範囲)761-774
ページ数14
ジャーナルStem Cell Reports
13
4
DOI
出版ステータス出版済み - 10 8 2019

All Science Journal Classification (ASJC) codes

  • 生化学
  • 遺伝学
  • 発生生物学
  • 細胞生物学

フィンガープリント

「Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル