Basics and recent advances in the pathophysiology of atopic dermatitis

Takeshi Nakahara, Makiko Kido-Nakahara, Gaku Tsuji, Masutaka Furue

研究成果: Contribution to journalReview article査読

3 被引用数 (Scopus)

抄録

Atopic dermatitis is a common, chronic inflammatory skin disease that is characterized by skin barrier dysfunction, inflammation and intense itch. Although the exact mechanisms behind its pathogenesis remain unclear, it is evident that the complex interplay among barrier dysfunction, inflammation and itch are critical in its development, progression and chronicity. Abnormalities in filaggrin, intercellular lipids and tight junctions induce barrier-disrupted skin, which produces thymic stromal lymphopoietin, interleukin (IL)-25 and IL-33; these in turn promote skin inflammation characterized by type 2 immune deviation. This inflammation then downregulates the expression of filaggrin in keratinocytes and exacerbates epidermal barrier dysfunction. Furthermore, various itch mediators/pruritogens produced during this inflammatory process can act directly on sensory nerves and cause itch. In this review, we summarize the basics and recent advances in our understanding of the pathophysiology of atopic dermatitis focusing on three aspects: barrier dysfunction, skin inflammation and itch.

本文言語英語
ページ(範囲)130-139
ページ数10
ジャーナルJournal of Dermatology
48
2
DOI
出版ステータス出版済み - 2 2021

All Science Journal Classification (ASJC) codes

  • Dermatology

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