Batf is important for IL-4 expression in T follicular helper cells

Anupama Sahoo, Andrei Alekseev, Kentaro Tanaka, Lidiya Obertas, Beatrisa Lerman, Cara Haymaker, Karen Clise-Dwyer, John S. McMurray, Roza Nurieva

研究成果: ジャーナルへの寄稿記事

33 引用 (Scopus)

抄録

Apart from T helper (Th)-2 cells, T follicular helper (Tfh) cells are a major class of IL-4-producing T cells, required for regulation of type 2 humoral immunity; however, transcriptional control of IL-4 production in Tfh cells remains mainly unknown. Here, we show that the basic leucine zipper transcription factor ATF-like, Batf is important for IL-4 expression in Tfh cells rather than in canonical Th2 cells. Functionally, Batf in cooperation with interferon regulatory factor (IRF) 4 along with Stat3 and Stat6 trigger IL-4 production in Tfh cells by directly binding to and activation of the CNS2 region in the IL-4 locus. In addition, Batf-to-c-Maf signalling is an important determinant of IL-4 expression in Tfh cells. Batf deficiency impairs the generation of IL-4-producing Tfh cells that results in protection against allergic asthma. Our results thus indicate a positive role of Batf in promoting the generation of pro-allergic IL-4-producing Tfh cells.

元の言語英語
記事番号7997
ジャーナルNature communications
6
DOI
出版物ステータス出版済み - 8 17 2015
外部発表Yes

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Helper-Inducer T-Lymphocytes
Interleukin-4
cells
Th2 Cells
Basic-Leucine Zipper Transcription Factors
F-22 aircraft
asthma
interferon
zippers
T-cells
leucine
Humoral Immunity
immunity
loci
determinants
Asthma
Chemical activation
actuators
T-Lymphocytes
activation

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

これを引用

Sahoo, A., Alekseev, A., Tanaka, K., Obertas, L., Lerman, B., Haymaker, C., ... Nurieva, R. (2015). Batf is important for IL-4 expression in T follicular helper cells. Nature communications, 6, [7997]. https://doi.org/10.1038/ncomms8997

Batf is important for IL-4 expression in T follicular helper cells. / Sahoo, Anupama; Alekseev, Andrei; Tanaka, Kentaro; Obertas, Lidiya; Lerman, Beatrisa; Haymaker, Cara; Clise-Dwyer, Karen; McMurray, John S.; Nurieva, Roza.

:: Nature communications, 巻 6, 7997, 17.08.2015.

研究成果: ジャーナルへの寄稿記事

Sahoo, A, Alekseev, A, Tanaka, K, Obertas, L, Lerman, B, Haymaker, C, Clise-Dwyer, K, McMurray, JS & Nurieva, R 2015, 'Batf is important for IL-4 expression in T follicular helper cells', Nature communications, 巻. 6, 7997. https://doi.org/10.1038/ncomms8997
Sahoo, Anupama ; Alekseev, Andrei ; Tanaka, Kentaro ; Obertas, Lidiya ; Lerman, Beatrisa ; Haymaker, Cara ; Clise-Dwyer, Karen ; McMurray, John S. ; Nurieva, Roza. / Batf is important for IL-4 expression in T follicular helper cells. :: Nature communications. 2015 ; 巻 6.
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