Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common γ chain-deficient mice

Motonari Kondo, Koichi Akashi, Jos Domen, Kazuo Sugamura, Irving L. Weissman

研究成果: Contribution to journalArticle査読

186 被引用数 (Scopus)

抄録

The common cytokine receptor γ chain (γ{c) is an indispensable subunit for the formation of lymphoid-related cytokine receptors, including IL-7 and IL-15 receptors, that mediate nonredundant or critical signals for the differentiation of T and B cells and natural killer (NK) cells, respectively. We introduced the bcl-2 transgene driven by Eμ or H-2K promoters into γ(c)-deficient mice that lack all three lymphoid subclasses. The forced expression of Bcl-2 restored all stages of T lymphopoiesis, but not B or NK cell development, indicating that a primary function of γ(c)- mediated signals in the T lineage might be to maintain cell survival. Therefore, the development of T, B, and NK cells may be influenced by distinct intracytoplasmic signaling cascades that are activated by coupling of γ(c)-related receptors.

本文言語英語
ページ(範囲)155-162
ページ数8
ジャーナルImmunity
7
1
DOI
出版ステータス出版済み - 7 1997
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学
  • 感染症

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